Laboratory renovation for translational synthetic and medicinal chemistry

转化合成和药物化学实验室改造

• 批准号: 7898371
• 负责人: Gloria S Waters
• 金额: $ 588.25万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-25 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7898371
• 关键词: American; Arts; Biochemistry; Biological Sciences; Biology; Biomedical Research; Boston; Chemicals; Chemistry; Collaborations; Construction Materials; Contractor; Development; Elements; Engineering; Equipment; Faculty; Funding; Goals; Industry; Laboratories; Laboratory Research; Libraries; Massachusetts; Methodology; Molecular; Occupations; Organic Synthesis; Pharmaceutical Chemistry; Recovery; Research; Research Personnel; Research Support; Rivers; Science; Scientist; System; Technology; Universities; design; design and construction; economic impact; flexibility; meetings; square foot; virtual

DESCRIPTION (provided by applicant): Boston University proposes to implement plans for the renovation of four laboratory modules consisting of 6,700 square feet of research and support space in the Metcalf Center for Science and Engineering on the University's Charles River Campus (CRC). This renovated space will directly support research efforts in synthetic and medicinal chemistry in three major undertakings: the Boston University Center for Molecular Discovery (BU-CMD), the Center for Chemical Methodology and Library Development (CMLD-BU), and the recruitment of two faculty with a biological chemistry focus in the Department of Chemistry. These renovations will solve three critical problems with the existing research space: (1) Inadequate or non-functional HVAC systems that are not energy efficient or flexible; (2) Deteriorating and inflexible casework that cannot be altered without contractor support; and (3) Compartmentalized laboratory layouts that limit the reassignment of space for optimal use as research needs evolve. The substantial expansion of research laboratories designed to support state-of-the-art organic synthesis, utilizing a flexible laboratory layout that will enable technology- facilitated medicinal chemistry, is a key element of the plan. Complementary development of faculty office and meeting space that fully supports real and virtual conferencing will be developed to facilitate engagement and collaboration between research scientists. While this request for C06 funding will clearly increase Boston University's ability to conduct biomedical research at the interface of chemistry and biology, the proposed project is consistent with the goals of the American Recovery and Reinvestment Act (ARRA). Besides requiring significant purchases in construction materials and research equipment, this $5.9 million renovation proposal will contribute jobs to the construction and life sciences industries, two key sectors in the Commonwealth of Massachusetts that have been significantly impacted by the economic downturn. During design and construction, the project will create or maintain 15 jobs related to the architectural, engineering, and constructions industries. It will also provide laboratory space for an additional 20 scientific researchers in the Department of Chemistry.

描述（由申请人提供）：波士顿大学提议实施计划，以翻新四个实验室模块，这些模块由METCALF科学与工程中心的Charles River校园（CRC）组成6,700平方英尺的研究和支持空间。经过翻新的空间将直接支持三项主要事业的合成和药物化学研究工作：波士顿大学分子发现中心（BU-CMD），化学方法论与图书馆发展中心（CMLD-BU），以及在化学系中以生物化学重点招募了两名具有生物学化学的教职员工。这些翻新将解决现有研究空间的三个关键问题：（1）不节能或灵活的HVAC系统不足或非功能性HVAC系统； （2）未经承包商支持就无法更改的恶化和僵化的案例； （3）隔间化的实验室布局，以限制了随着研究需求的发展，可以重新分配空间以进行最佳使用。旨在支持最先进的有机综合的研究实验室的大量扩展是利用灵活的实验室布局，该实验室的布局将使技术有助于技术化学，这是该计划的关键要素。将开发充分支持真实和虚拟会议的教师办公室和会议空间的互补发展，以促进研究科学家之间的参与和协作。虽然该对C06资金的要求将显然提高波士顿大学在化学和生物学界面进行生物医学研究的能力，但拟议项目与《美国恢复和再投资法》（ARRA）的目标一致。除了需要在建筑材料和研究设备上进行大量购买外，这项590万美元的翻新建议还将为建筑和生命科学行业提供就业机会，这是马萨诸塞州联邦的两个关键部门，这些部门受到经济下滑的重大影响。在设计和构建过程中，该项目将创建或维护与建筑，工程和建筑行业有关的15个工作。它还将为化学系的另外20位科学研究人员提供实验室空间。