Patient-oriented research in early life origins of CVD

以患者为中心的 CVD 生命早期起源研究

• 批准号: 7083404
• 负责人: MATTHEW W GILLMAN
• 金额: $ 17.82万
• 依托单位: HARVARD PILGRIM HEALTH CARE, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7083404
• 关键词: adiponectin; adolescence (12-20); asthma; blood pressure; body physical activity; breast feeding; cardiovascular disorder epidemiology; cardiovascular disorder risk; child (0-11); child physical development; clinical research; cognition; corticotropin releasing factor; diet; early experience; human data; human pregnant subject; human subject; longitudinal human study; mother /embryo /fetus nutrition; nutrition related tag; obesity; patient oriented research; questionnaires; unsaturated fatty acids

DESCRIPTION (provided by applicant): Factors operating not only in adult life, but also from conception, have impact on lifelong cardiovascular health. Animal and human studies, including our own, are now providing intriguing clues into the pre- and perinatal determinants of childhood obesity and cardiovascular risk. But prospective data are lacking, and translation into preventive interventions has only just begun. With the support from this K24 competing continuation grant, Dr. Gillman and his mentees will focus intensively on this area of research for the next five years, a critical period not only for the field itself, but also for continuing to expand his potential for significant contributions and for nurturing the next generation of patient-oriented researchers in this field. The specific aims of this proposal are (1) To examine pre- and perinatal determinants of childhood obesity and cardiovascular risk factors. These analyses will take advantage of the infrastructure provided by the ongoing NIH-funded Project Viva, a prospective cohort study of pregnant women and their children. (2) To provide a nourishing professional environment for the training and advancement of beginning clinical researchers, who will conduct studies within Project Viva and other ongoing patient-oriented research projects in the area of the life course approach to chronic disease. Major foci will be in the areas of (1) pre- and perinatal origins of obesity, cardiovascular risk, asthma, and cognition; (2) determinants of diet and physical activity in adolescence; and (3) innovative interventions to prevent obesity in young children.

描述（由申请人提供）： 不仅在成人生活中运作的因素，而且在构想中也会影响终身性心血管健康。现在，包括我们自己的动物和人类研究正在为儿童肥胖和心血管风险的前和周围决定因素提供有趣的线索。但是缺乏前瞻性数据，而转化为预防性干预措施才刚刚开始。在这项K24竞争持续赠款的支持下，吉尔曼博士和他的受训者将在接下来的五年内将重点放在这一研究领域，这不仅是该领域本身的关键时期，而且还要继续扩大其潜在的重要贡献，并培育了该领域中下一代患者的下一代研究人员。该提案的具体目的是（1）检查儿童肥胖症和心血管危险因素的前和周围决定因素。这些分析将利用正在进行的NIH资助项目Viva提供的基础设施，这是对孕妇及其子女的前瞻性队列研究。 （2）为培训和进步提供了滋养专业的环境，他们将在Viva项目和其他正在进行的以患者为导向的研究项目中进行慢性疾病的方法进行研究。主要的焦点将在（1）肥胖，心血管风险，哮喘和认知的（1）围产期和围产期起源的区域； （2）青春期饮食和体育活动的决定因素； （3）防止幼儿肥胖的创新干预措施。