Award:Alcohol-Related Human Disease Research

奖项：与酒精相关的人类疾病研究

• 批准号: 7081677
• 负责人: SUZANNE M. DE LA MONTE
• 金额: $ 14.89万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-20 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7081677
• 关键词: acetylcholinesterase; alcoholism /alcohol abuse; apoptosis; biological signal transduction; brain cell; choline acetyltransferase; clinical research; disease /disorder etiology; enzyme activity; ethanol; fluorescence microscopy; human tissue; insulin; insulin receptor; laboratory rat; mitochondria; neural degeneration; neuropathology; neurotoxicology; pathologic process; patient oriented research; polymerase chain reaction; protein tyrosine phosphatase; substance abuse related behavior; tissue resource /registry

DESCRIPTION (provided by applicant): Alcohol abuse is the single most common known and preventable cause of birth defects, and a major contributor to both chronic liver disease and neurodegeneration in the United States. Our research has linked several chronic alcohol exposure-mediated abnormalities in brain and liver function to impairments in insulin and insulin-like growth factor signaling, particularly with regard to cell survival and energy metabolism. However, in order to capitalize on these recent gains, it will be necessary to extend the analyses to human disease states using state-of-the-art methodology. The major goals of this proposal are to: 1) investigate mechanisms of alcohol-mediated neurodegeneration in adult human brains using molecular and biochemical approaches; 2) provide a strong, highly supportive environment to train and mentor junior investigators, particularly physician-scientists, to investigate human disease mechanisms by utilizing current technology to analyze human tissue samples; and 3) educate junior investigators about the importance of experimental models for testing hypotheses and validating results from human studies. Emphasis will be placed on including women and minority trainees. Suzanne M. De la Monte is a Pathologist and Neuropathologist by training and clinical activities at the Rhode Island Hospital, and Professor of Pathology and Clinical Neuroscience at Brown University. Dr. De la Monte has a long track record of training young investigators in human disease, biomedical, and translational research. Her laboratory, which currently is supported by NIH funding from NIAAA, hosts several trainees including undergraduates, medical students, graduate students, postdoctoral fellows, and junior physician-scientists, most of whom are women or members of under-represented minority groups. This Mid-career investigator award will provide better opportunity for Dr. De la Monte to exercise leadership and high quality mentorship and training of promising young scientists. The information included in this application demonstrates a productive career in human and translational research, and demonstrates Dr. De la Monte's commitment to continuing this type of work while mentoring scientists for the future.

描述（由申请人提供）：酗酒是最常见和可预防的先天缺陷原因，也是美国慢性肝病和神经退行性的主要贡献者。我们的研究已将大脑和肝功能中的几种慢性酒精暴露介导的异常与胰岛素和胰岛素样生长因子信号传导的损害联系起来，尤其是在细胞存活和能量代谢方面。但是，为了利用这些最近的收益，有必要使用最先进的方法将分析扩展到人类疾病状态。该提案的主要目标是：1）使用分子和生化方法研究了成年人大脑中酒精介导的神经退行性的机制； 2）为培训和指导初级研究人员，特别是医师科学家提供一个强大的支持环境，通过利用当前技术来分析人类组织样本来研究人类疾病机制； 3）教育初级调查人员有关的重要性 测试假设和验证人类研究结果的实验​​模型。重点将放在包括妇女和少数族裔学员。 Suzanne M. de la Monte是罗德岛医院的培训和临床活动的病理学家和神经病理学家，以及布朗大学病理学和临床神经科学教授。 De La Monte博士在培训人类疾病，生物医学和转化研究的年轻研究人员方面有着悠久的记录。她的实验室目前得到了NIAAA的NIH资助的支持，包括多个学员，包括本科生，医学生，研究生，博士后研究员和初级医师 - 科学家，其中大多数是女性或代表性不足的少数群体的成员。这项职业中期调查员奖将为De La Monte博士提供更好的机会，以行使领导力和高质量的指导以及对年轻科学家的培训。本应用程序中包含的信息展示了人类和翻译研究中的富有成效的职业，并证明了德拉蒙特博士致力于继续这类工作的同时指导科学家的未来。