Effect of Neonatal Insult on Adult Visceral Afferents

新生儿侮辱对成人内脏传入的影响

• 批准号: 6999616
• 负责人: Julie A Carlsten Christianson
• 金额: $ 4.72万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-10 至 2007-06-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999616
• 关键词: behavioral /social science research tag; colon disorder; dorsal horn; electromyography; gastrointestinal sign /symptom; hyperalgesia; immunocytochemistry; inflammation; laboratory mouse; neural information processing; neural plasticity; neurochemistry; pain; phenotype; postdoctoral investigator; psychoneuroimmunology; spinal ganglion; visceral afferent nerve

DESCRIPTION (provided by applicant): Inflammation or pain during early neonatal development results in long-term structural and functional alterations in nociceptive processing. While this phenomenon has been extensively studied within the somatosensory system, the impact of neonatal inflammation on the viscerosensory system is relatively unknown. This proposal has been designed to address the long-term effects of neonatal colon inflammation on the processing of visceral pain in adult mice. A model of neonatal colonic inflammation in mice will be used to determine if permanent changes can be induced in anatomical and physiological properties of visceral afferents, causing them to become permanently sensitized and thereby establishing a state of chronic visceral hyperalgesia. Using a combination of anatomical and physiological techniques, changes will be investigated in 1) the central and peripheral termination patterns and spinal organization of colonic afferents, 2) nocifensive responses to noxious stimuli and 3) the electrophysiological response patterns of colonic afferents. The data obtained here will provide important information regarding the plasticity of the viscerosensory system during neonatal periods.

描述（由申请人提供）：早期新生儿发育期间的炎症或疼痛导致伤害性处理的长期结构和功能改变。尽管这种现象在体感系统中进行了广泛的研究，但新生儿炎症对内脏感体系的影响相对尚不清楚。该提案旨在解决新生儿结肠炎症对成年小鼠内脏疼痛处理的长期影响。小鼠的新生儿结肠炎症模型将用于确定内脏传入的解剖学和生理特性是否可以诱导永久性变化，从而导致它们永久敏感并从而建立慢性内脏伴侣的状态。使用解剖学和生理技术的结合，将在1）结肠传入的中心和周围终止模式和脊柱组织中进行研究，2）对有害刺激的单化反应和3）结肠传统的电生理响应模式。此处获得的数据将提供有关新生儿时期内脏系统可塑性的重要信息。