Inhibitory interneurons in fear cond. and extinction

恐惧条件下的抑制性中间神经元。

• 批准号: 6943110
• 负责人: JASMEER P CHHATWAL
• 金额: $ 2.54万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943110
• 关键词: amygdala; behavioral /social science research tag; biological signal transduction; biomarker; cell cell interaction; cell population study; conditioning; fear; genetic regulation; immunocytochemistry; interneurons; laboratory rat; learning; molecular psychobiology; neural information processing; neural plasticity; neuroanatomy; neurogenetics; neuropharmacologic agent; neuropharmacology; neuroregulation; predoctoral investigator; protein localization; protein structure function; transcription factor

DESCRIPTION (provided by applicant): Both the learning of an aversive CS-US pairing in classical fear conditioning and the extinction of a fear response critically rely on the amygdala to occur. Additionally, several lines of evidence suggest that extinction learning is not simply an erasure of the original fear memory, but a distinct and parallel form of learning that suppresses the expression of the conditioned fear response. Thus there appear to be two forms of learning that occur in the basolateral amygdala which have opposing effects on the expression of conditioned fear through the output of the amygdala (the central nucleus). We hypothesize that these two forms of learning will produce differential patterns of second-messenger and transcription factor activation within the sub-populations of excitatory and inhibitory neurons that constitute the associative learning circuit in the basolateral complex of the amygdala (BLA). Furthermore, we hypothesize that by using pharmacologic and genetic manipulations targeting one particular sub-population of BLA neurons, we may be able to selectively alter one of these two types of learning while leaving the other intact.

描述（由申请人提供）：经典恐惧条件反射中厌恶性 CS-US 配对的学习和恐惧反应的消失都严重依赖于杏仁核的发生。此外，一些证据表明，消退学习不仅仅是原始恐惧记忆的擦除，而是一种独特且平行的学习形式，可以抑制条件性恐惧反应的表达。因此，基底外侧杏仁核中似乎存在两种形式的学习，它们对通过杏仁核（中央核）的输出表达条件性恐惧具有相反的作用。我们假设这两种形式的学习将在兴奋性和抑制性神经元亚群中产生第二信使和转录因子激活的差异模式，这些神经元构成杏仁核基底外侧复合体（BLA）中的联想学习回路。此外，我们假设通过针对 BLA 神经元的一个特定亚群使用药理学和遗传操作，我们可能能够选择性地改变这两种类型的学习中的一种，同时保持另一种完好无损。