Ethanol drinking, depression, and neurogenesis

饮酒、抑郁和神经发生

• 批准号: 7057680
• 负责人: JENNIFER R HILLMANN
• 金额: $ 2.73万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-13 至 2007-09-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7057680
• 关键词: alcoholic beverage consumption; antidepressants; behavioral /social science research tag; brain electrical activity; brain mapping; depression; drug /alcohol abstinence; ethanol; ethology; immunocytochemistry; laboratory mouse; mental health epidemiology; neurogenesis; neurotoxicology; predoctoral investigator; psychopharmacology

DESCRIPTION (provided by applicant): Experiments in this proposal will determine if and how cessation of ethanol drinking can produce depression like behavior, and also if cessation of ethanol drinking, when ethanol is consumed voluntarily, produces decreases in adult neurogenesis. Experiments will characterize the time course over which depression-like behavior emerges following cessation of ethanol drinking and also if sub-chronic ethanol drinking produces depression-like behavior. C-fos immunohistochemistry will be used to determine areas of the brain, which are activated in mice that express alcohol-induced depression-like behavior and mice that have not consumed alcohol and do not express depression-like behavior. Changes in neurogenesis due to cessation of voluntary ethanol drinking will be characterized. Experiments will involve testing pharmacotherapies with antidepressant potential to determine if they can reverse depression-like behavior induced by cessation of ethanol drinking.

描述（由申请人提供）：本提案中的实验将确定乙醇饮用的停止以及如何产生诸如行为之类的抑郁症，以及当自愿消耗乙醇时，乙醇饮用的停止是否会导致成人神经发生的降低。实验将表征在停止乙醇饮用后出现抑郁症行为的时间过程，以及亚气乙醇饮酒会产生类似抑郁症的行为。 C-FOS免疫组织化学将用于确定大脑的区域，这些区域在表达酒精引起的抑郁症行为的小鼠中被激活，并且没有消耗酒精并且不表达抑郁症的行为的小鼠。由于停止而导致的神经发生变化 自愿性乙醇饮用的特征。实验将涉及测试具有抗抑郁潜力的药物治疗，以确定它们是否可以逆转抑制乙醇饮用的抑郁样行为。