Effects of gonadal hormones during puberty on behavior

青春期性激素对行为的影响

• 批准号: 6891248
• 负责人: KALYNN SCHULZ
• 金额: $ 2.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2007-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891248
• 关键词: animal puberty; behavioral /social science research tag; dopamine; dopamine receptor; ethology; gonads; hamsters; high performance liquid chromatography; male; male castration; neuroendocrine system; predoctoral investigator; preoptic areas; reproduction; sex behavior; statistics /biometry; steroid hormone; testosterone

DESCRIPTION (provided by applicant): The primary aim of this research is to understand how gonadal steroid hormones shape the nervous system and behavior during puberty in male hamsters. While the pubertal rise in testosterone (T) is often associated with the activation of male reproductive behavior, these T secretions also organize (i.e., permanently alter) developing neural circuits to enhance activational responses to T in adulthood. Exp. 1 will test the hypothesis that puberty is a sensitive period for organizational actions of T on masculine reproductive behavior. Specific Aim 2 will determine whether T during puberty organizes masculine reproductive behavior by altering medial preoptic area dopaminergic responses to female sensory stimuli. These studies have implications for human conditions such as anabolic steroid abuse, eating disorders, and disease, all of which shift the window of brain exposure to steroid hormones outside of the normal time of puberty.

描述（由申请人提供）：本研究的主要目的是了解性腺类固醇激素如何塑造雄性仓鼠青春期的神经系统和行为。虽然青春期睾酮 (T) 的升高通常与男性生殖行为的激活有关，但这些 T 分泌物也会组织（即永久改变）发育中的神经回路，以增强成年期对 T 的激活反应。过期。图1将检验这样的假设：青春期是T的组织行为对男性生殖行为的敏感时期。具体目标 2 将确定青春期期间 T 是否通过改变内侧视前区对女性感觉刺激的多巴胺能反应来组织男性生殖行为。这些研究对合成代谢类固醇滥用、饮食失调和疾病等人类状况具有影响，所有这些都会将大脑暴露于类固醇激素的时间窗口移到正常青春期之外。