ULTRASONIC ELASTICITY IMAGING OF THE BREAST

乳房超声弹性成像

• 批准号: 6633471
• 负责人: Michael F Insana
• 金额: $ 31.11万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6633471
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; clinical research; diagnosis design /evaluation; elasticity; female; human subject; mathematical model; phantom model; technology /technique development; ultrasonography

DESCRIPTION (Adapted from Applicant's Abstract): Check ThisThe objective of this project is the development of elasticity imaging as a new approach to medical imaging for detection of cancer and monitoring for recurrence. In this research, images are formed by comparing ultrasonic echoes recorded before and after a small physical compression of the tissue. The comparison provides a determination of local tissue displacement that is used to estimate longitudinal strain along the axis of the sound beam. Strain imaging in this way is a kind of palpation technique that reveals stiffness variations in tissues with higher sensitivity and spatial resolution than manual palpation. The proposed approach, which builds on four years of previous research, has six specific aims: 1) Develop robust image formation algorithms for breast imaging. 2) Work with industry to design instrumentation for strain imaging of the breast. 3) Use phantoms to develop breast-tissue-restraining devices. 4) Conduct preliminary clinical trials on human subjects. 5) Examine the diagnostic potential of other elasticity parameters. 6) Assess the performance of developing techniques for the important clinical problem of diagnosing and managing breast disease.

描述（改编自申请人的摘要）：勾选此目标 该项目是弹性成像的发展作为一种新方法 用于检测癌症和监测复发的医学成像。在这个 研究中，通过比较之前记录的超声波回波和之前记录的超声波回波来形成图像 对组织进行轻微的物理压缩后。比较提供了 确定用于估计的局部组织位移 沿声束轴的纵向应变。应变成像 方式是一种触诊技术，可揭示刚度变化 与手动触诊相比，具有更高灵敏度和空间分辨率的组织。 所提出的方法建立在之前四年研究的基础上，有六个 具体目标： 1）开发用于乳腺成像的鲁棒图像形成算法。 2）与工业界合作设计用于应变成像的仪器 胸部。 3) 使用模型开发乳房组织约束装置。 4） 对人体进行初步临床试验。 5) 检查 其他弹性参数的诊断潜力。 6）评估绩效 开发技术来解决诊断和治疗这一重要的临床问题 管理乳腺疾病。