Relaxation response with acupuncture for HIV patients

针灸对艾滋病毒患者的放松反应

• 批准号: 6654769
• 负责人: Bei-Hung Chang
• 金额: $ 15.75万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6654769
• 关键词: AIDS; AIDS therapy; HIV infections; acupuncture /acupressure; alternative medicine; clinical research; combination therapy; human subject; human therapy evaluation; patient oriented research; quality of life; relaxation; self care

DESCRIPTION (provided by applicant): Although recent changes in HIV/AIDS treatment have resulted in dramatic declines in morbidity and mortality nationwide, disease management and quality of life among HIV/AIDS patients continue to be of concern. HIV/AIDS patients experience a range of symptoms associated with clinical manifestations of the disease, opportunistic infections, and medication side effects, all of which are strongly associated with quality of life (QoL). Many HIV/AIDS patients use complementary and alternative medicine (CAM) to help alleviate their symptoms and to improve their QoL. Among the various CAMs, acupuncture and relaxation response are commonly used regimens. These two therapies are thought to share common features and can complement each other in that acupuncture facilitates the effect of relaxation response and on the other hand relaxation response prepares the body to be more accessible to acupuncture. The clinical effects of each of these two therapies alone have been shown in numerous studies. However, no study has investigated the combined effects of these two regimens. We therefore propose an exploratory study to test the feasibility of conducting a double blind 2-arm controlled trial and to collect pilot data in preparation for a large-scale study to fully test the hypothesis that adding relaxation response to acupuncture will have an enhanced effect in HIV+ patients. For this pilot study, we will recruit 100 HIV+ patients who are currently receiving acupuncture. Study participants in the intervention group will listen to tapes with instructions to elicit the relaxation response as well as music routinely played while receiving acupuncture. Study participants in the control group will receive usual care that is listening to music while receiving acupuncture. Study participants in both groups will be given the respective tapes for home practice and they are asked to record the frequency of usage. We will assess both groups' symptoms and quality of life at baseline, 4 weeks, 8 weeks, and upon completion of the intervention at 12 weeks. We will assess the feasibility using various indicators, including patient evaluation of the study. Ultimately, the qualitative analysis of patients' study evaluation as well as the longitudinal regression analysis results that compare the outcomes between the intervention and control groups will be used to help design a future large-scale study of the relaxation response intervention among HIV+ patients treated with acupuncture.

描述（由申请人提供）：尽管最近艾滋病毒/艾滋病治疗的变化已导致全国范围内的发病率和死亡率急剧下降，但艾滋病毒/艾滋病患者的疾病管理和生活质量仍然令人担忧。 HIV/艾滋病患者会经历一系列与疾病临床表现、机会性感染和药物副作用相关的症状，所有这些都与生活质量 (QoL) 密切相关。许多艾滋病毒/艾滋病患者使用补充和替代医学 (CAM) 来帮助缓解症状并提高生活质量。在各种 CAM 中，针灸和放松反应是常用的疗法。这两种疗法被认为具有共同的特点，并且可以相互补充，因为针灸促进放松反应的效果，另一方面放松反应使身体更容易接受针灸。大量研究已经证明了这两种疗法各自的临床效果。然而，还没有研究调查这两种方案的综合效果。因此，我们提出一项探索性研究，以测试进行双盲双臂对照试验的可行性，并收集试点数据，为大规模研究做准备，以充分检验针灸添加放松反应将增强针灸治疗效果的假设。 HIV+患者。在这项试点研究中，我们将招募 100 名目前正在接受针灸治疗的 HIV+ 患者。干预组的研究参与者将听带有引发放松反应说明的磁带以及接受针灸时常规播放的音乐。对照组的研究参与者将接受常规护理，即在接受针灸的同时听音乐。两组研究参与者都会获得各自的磁带用于家庭练习，并要求他们记录使用频率。我们将在基线、第 4 周、第 8 周以及干预完成后第 12 周评估两组的症状和生活质量。我们将使用各种指标评估可行性，包括患者对研究的评估。最终，对患者研究评估的定性分析以及比较干预组和对照组结果的纵向回归分析结果将有助于设计未来针对接受治疗的 HIV+ 患者放松反应干预的大规模研究。针刺。