Exploiting Nutrition on Delay Cataract

利用营养延缓白内障发生

• 批准号: 6875387
• 负责人: ALLEN TAYLOR
• 金额: $ 16.35万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875387
• 关键词: cataract; clinical research; cooperative study; dietary carbohydrates; dietary lipid; disease /disorder proneness /risk; essential fatty acids; female; human data; human middle age (35-64); human old age (65+); human subject; longitudinal human study; nutrient requirement; nutrition related tag; nutritional epidemiology; vitamin deficiency

DESCRIPTION (provided by applicant): Cataract, or opacification of the lens, is a major cause of visual disability. Cataract extraction is the most frequently performed surgery and costs for cataract-related problems account for the largest line item in the Medicare budget. Delaying cataract by 10 years would halve the number of cataract extractions and save over $1 billion annually. Studies suggest that nutrition may be exploited to diminish the prevalence of or retard the progress of age-related cataract. However, there is little epidemiologic research regarding relations between major components of diet (other than for antioxidants) and risk for prevalence or progress of cataract. This knowledge is important in order to know if people at high risk or with early lens opacities might benefit from proper dietary management. This NEI R03 proposal from the Nutrition and Vision Project (NVP) - a collaboration between Tufts University and the Nurses' Health Study (NHS) at Harvard University and Harvard Medical School - exploits unique existing ophthalmologic and nutritional databases to assess three previously untested hypotheses about the extent to which nutrition affects risk for prevalence and progress of opacification. The NVP ophthalmologic data set includes two sets of graded lens images, gathered five years apart, from 451 women (ages 53-73 y) who are a subset of the NHS. The NHS data set includes long-term nutritional data from 5 food frequency questionnaires and a plethora of data on other personal and environmental factors, all gathered during a 15-year period before the baseline eye exam. Combined, these data will be used to test three hypotheses: that risk for cataract is lower in persons who a) consume higher levels of specific fats (monounsaturated, polyunsaturated, and saturated dietary fats, n-3 fatty acids, etc.), b) consume lower glycemic index foods, and c) eat according to particular dietary patterns.

描述（由申请人提供）：白内障或镜头的不透明是视觉障碍的主要原因。白内障提取是医疗保险预算中最大的终点项目的最常见的手术和与白内障有关的问题的成本。将白内障延迟10年将减少白内障的数量，每年节省超过10亿美元。研究表明，可以利用营养来减少与年龄相关性白内障的进展的患病率或延迟。但是，关于饮食的主要组成部分（除抗氧化剂）和白内障患病率或进度的风险之间，几乎没有流行病学研究。这些知识对于知道高风险或具有早期晶状体不熟悉的人可能受益于适当的饮食管理很重要。这项NEI R03来自营养和视觉项目（NVP）的NEI R03 - 哈佛大学和哈佛大学的护士健康研究（NHS）之间的合作，利用了独特的现有的眼科数据库，以评估三个先前未经测试的营养范围对这种范围的范围，从而影响了对这种营养的影响，从而对风险进行了进步，并影响了进步和进步。 NVP眼科数据集包括两组分级镜头图像，相距五年，从451名女性（53-73岁）（年龄在53-73岁）中，这是NHS的一部分。 NHS数据集包括来自5项食品频率问卷的长期营养数据，以及有关其他个人和环境因素的大量数据，所有数据都在基线眼检查之前的15年内收集。结合这些数据将用于检验三个假设：在a）食用更高水平的特定脂肪（单不饱和，多不饱和和饱和饮食脂肪的人中，白内障的风险较低，n-3脂肪酸等，n-3脂肪酸等），b）饮食下饮食的饮食习惯。