Concordance of Clinical and Quality of Life Measures

临床和生活质量测量的一致性

• 批准号: 6925825
• 负责人: PATRICIA A WREN
• 金额: $ 22.95万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-15 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6925825
• 关键词: behavioral /social science research tag; binocular vision; clinical research; data collection methodology /evaluation; glaucoma; glaucoma test; human data; pathologic process; quality of life; vision disorders; vision tests; visual fields; visual perception; behavioral /social science research tag; binocular vision; clinical research; data collection methodology /evaluation; glaucoma; glaucoma test; human data; pathologic process; quality of life; vision disorders; vision tests; visual fields; visual perception

DESCRIPTION (provided by applicant): The overarching purpose of this proposal is to establish the concordance between clinical parameters and vision specific quality of life (QOL) using the extensive, longitudinal dataset available from the Collaborative Initial Glaucoma Treatment Study (CIGTS). We will be addressing the following specific aims: Aim #1: To explore whether binocular clinical measures correlate more strongly than monocular measures with patients' perceptions of their visual function. The binocular measures which will be considered include the Esterman visual field (VF) score, simulated measures of the binocular VF, and the binocular visual acuity (VA) score; the monocular measures include the better and worse eye VF and VA scores. Aim #2: To establish the relationship between the location of VF damage and patients' appraisal of their visual function. For example, are patients more likely to experience problems reading small print if they have central and/or paracentral VF loss; or are patients who report trouble changing lanes in traffic or seeing objects coming from the side more likely to have experienced peripheral VF damage? Aim #3: To determine if the relationship between VF progression and patients' perceptions is linear, or must damage progress beyond a certain threshold before patients can discern changes in their visual function. Aim #4: To compare and contrast the various vision-specific QOL measures (i.e., VAQ, NEI-VFQ, and Symptom Impact-Visual Function subscale) in terms of the strength of their responsiveness to clinically relevant VF progression and changes in VA.

描述（由申请人提供）：该提案的总体目的是使用从协作初始青光眼治疗研究（CIGTS）可用的广泛的纵向数据集建立临床参数和视觉特定生活质量（QOL）之间的一致性。我们将解决以下具体目标： 目标＃1：探索双眼临床测量是否比单眼措施与患者对视觉功能的看法更强烈。被视为的双眼度量包括埃斯特曼视野（VF）得分，双眼VF的模拟度量以及双眼视力（VA）得分；单眼措施包括更好和差的眼VF和VA分数。 目标＃2：建立VF损伤位置与患者对其视觉功能的评估之间的关系。例如，如果患者患有中央和/或中心VF损失，则更有可能遇到问题的问题；还是报告说换车道路或看到来自侧面的物体的患者更有可能遭受外围VF损害？ 目标＃3：确定VF进展与患者的看法之间的关系是线性的，还是必须损害进展，超出一定阈值，才能辨别出视觉功能的变化。 目的＃4：以其对临床相关的VF进展和VA中的变化的响应强度，比较和对比各种视力特定的QoL措施（即VAQ，NEI-VFQ和症状影响 - 视觉功能子量表）。