Massage to Enhance Quality of Life in ASCT Patients

按摩提高 ASCT 患者的生活质量

• 批准号: 6933191
• 负责人: ANN GILL TAYLOR
• 金额: $ 20.59万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933191
• 关键词: adult human (21+); autologous transplantation; behavioral /social science research tag; cancer pain; clinical research; combination cancer therapy; data collection methodology /evaluation; human subject; human therapy evaluation; massage therapy; medical complication; neoplasm /cancer chemotherapy; neoplasm /cancer radiation therapy; outcomes research; pain; patient care management; physiologic stressor; psychological aspect of cancer; psychological stressor; quality of life; questionnaires; stem cell transplantation

DESCRIPTION (provided by applicant) Patients with cancer undergoing autologous stem cell transplantation (ASCT) endure stressors and symptoms throughout treatment, resulting in greatly impaired quality of life (QoL). Despite advances in conventional symptom management, patients often experience significant emotional distress (anxiety, stress, and depressive symptoms), pain, fatigue, nausea, and vomiting prior to and following ASCT. Psychosocial interventions that alleviate stress and induce relaxation can reduce treatment-related symptoms and improve QoL in many patients with cancer. However, some patients are not responsive to these approaches, and more passive therapies may be preferred by patients with impaired concentration and/or fatigue. This revised exploratory application proposes a novel seven-week massage therapy intervention that potentially could reduce symptoms and improve QoL. The study will utilize a prospective, randomized two-group design. Thirty-two patients with cancer (ages >= 18) scheduled to receive ASCT at the University of Virginia Cancer Center will be recruited, evaluated with baseline measures, and randomly assigned to receive either: (1) standard medical care alone (SMC); or (2) SMC plus seven weeks of massage therapy. Patients will complete weekly questionnaires (QoL, symptoms) during the intervention period. The primary aims of the study are to explore: 1) the feasibility of the study design and massage intervention protocol; and 2) the estimation of the changes in QoL and symptoms over time in each group (massage and SMC). The stressors and symptoms of ASCT could potentially reduce cardiac vagal tone, and massage has been demonstrated to stimulate parasympathetic outflow. Thus, the investigators propose a secondary aim to explore the use of power spectral analysis of short-term heart rate variability (HRV) in obtaining preliminary estimates of immediate and/or cumulative changes in parasympathetic tone (high frequency component of HRV) after either massage (treatment group) or rest (SMC group). These analyses will provide the foundation for designing a large multi-site RCT (R01) that will examine the effects and mechanisms of massage therapy for patients with cancer undergoing ASCT

描述（由申请人提供） 经受自体干细胞移植（ASCT）耐力的癌症患者在整个治疗过程中耐力症状和症状，从而极大地损害了生活质量（QOL）。尽管常规症状管理进展，但患者在ASCT之前和关注之前经常遭受严重的情绪困扰（焦虑，压力和抑郁症状），疼痛，疲劳，恶心和呕吐。减轻压力和诱发放松的社会心理干预措施可以减轻许多癌症患者的治疗症状并改善QOL。但是，有些患者对这些方法没有反应，并且浓度受损和/或疲劳的患者可能会更喜欢被动疗法。这项修订的探索性应用提出了一种新型的为期7周的按摩疗法干预措施，可能会减轻症状并改善质量质量。该研究将利用前瞻性的两组设计。计划在弗吉尼亚大学癌症中心接受ASCT的32例癌症患者（年龄> = 18）将被招募，对基线措施进行评估，并随机分配接受：（1）仅标准医疗服务（SMC）；或（2）SMC加七周的按摩疗法。患者将在干预期间完成每周问卷（QOL，症状）。该研究的主要目的是探索：1）研究设计和按摩干预方案的可行性； 2）估计每组QOL和症状随时间变化的估计（按摩和SMC）。 ASCT的压力源和症状可能有可能降低心迷走神经音调，并且已证明按摩可以刺激副交感神经流出。因此，研究人员提出了次要的目的，旨在探讨短期心率变异性（HRV）的功率谱分析，以获取副交感神经张力（按摩组（治疗组）或REST（SMC组）的副交感神经（HRV的高频率成分）的直接和/或累积变化的初步估计。这些分析将为设计大型多站点RCT（R01）提供基础