Development of a Novel Gas Embolotherapy Technique

新型气体栓塞治疗技术的开发

基本信息

批准号：
6862622
负责人：
JOSEPH L BULL
金额：
$ 18.05万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-04-01 至 2007-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6862622
关键词：
air embolism albumins fluosol hepatocellular carcinoma human therapy evaluation laboratory rabbit necrosis neoplasm /cancer blood supply neoplasm /cancer therapy therapeutic blood vessel occlusion therapy design /development ultrasound

项目摘要

DESCRIPTION (provided by applicant): The delivery of emboli to arterial blood flow with the goal of flow occlusion, or embolotherapy, is a potential means to treat a variety of cancers, such as heptatocellular carcinoma (HCC) and renal carcinoma. HCC, the most common form of liver cancer, occurs in 2-30 per 100,000 males each year, resulting in approximately 1,250,000 deaths worldwide annually. The accompanying liver cirrhosis makes the treatment of HCC by traditional methods difficult. Systemic chemotherapy has no appreciable impact on survival rates. In addition to these types of cancer, many other types could potentially be treated using embototherapy. Previous attempts at embolotherapy have used solid emboli, such as blood clot, gelatin sponge, particulates, balloons and streamers. A major difficulty in embolotherapy is restricting delivery of the emboli to the tumor, i.e. minimizing ischemia of healthy tissue, without extremely invasive procedures. Here, we propose an acoustically activated gas embolotherapy. While gas bubbles have been used as ultrasonic contrast agents, they have not previously been used to occlude flow to tumors. Moreover, this novel approach involves introducing liquid droplets, which are small enough to pass through capillaries, into the vascular flow. The droplets could be tracked using ultrasound and vaporized via high intensity ultrasound near the tumor allowing gas bubbles, which are considerably larger than the liquid drops from which they originated, to occlude flow in the tumor. This minimally invasive technique would allow selective delivery of gas emboli to the tumor, and is well suited to repeated doses and long term use. The proposed research uses computational and experimental (animal and bench top) studies to provide proof of concept of this technique. This work will investigate the physical phenomena of vessel occlusion by gas emboli and vessel deformation due to the vaporization of liquid droplets. The proposed research is a collaboration of engineers, physicists, and clinicians with expertise in expertise in fluid dynamics, gas transport, and diagnostic and therapeutic ultrasound. The proposed research is an essential first step in developing this potentially revolutionary technique.

描述（由申请人提供）：将栓子递送到动脉血流中，其目的是闭塞或栓塞疗法，是治疗各种癌症的潜在手段，例如亨氏细胞癌（HCC）和肾癌。 HCC是肝癌最常见的形式，每年每年有2-30名男性发生，每年在全球范围内约1,250,000人死亡。随附的肝肝硬化使传统方法难以治疗HCC。全身化疗对生存率没有明显的影响。除了这些类型的癌症之外，许多其他类型的可能会使用疗法治疗。先前对栓塞疗法的尝试使用了固体栓子，例如血凝块，明胶海绵，颗粒，气球和彩带。栓塞疗法的主要困难是将栓子递送到肿瘤，即在没有极为侵入性手术的情况下最大程度地减少健康组织缺血。在这里，我们提出了一种声学活化的气体和疗法。虽然气泡已被用作超声造影剂，但以前尚未使用它们来阻塞流向肿瘤的流动。此外，这种新颖的方法涉及引入液滴，该液滴足够小，可以通过毛细血管进入血管流。可以使用超声跟踪液滴，并通过肿瘤附近的高强度超声进行蒸发，从而使气泡允许气泡，这比其起源的液滴大得多，以闭塞肿瘤中的流动。这种微创技术将使气体栓塞选择性递送到肿瘤，并且非常适合重复剂量和长期使用。拟议的研究使用计算和实验性（动物和台式）研究来提供该技术概念证明。这项工作将研究由于液滴蒸发而导致气体栓塞和血管变形的血管阻塞的物理现象。拟议的研究是工程师，物理学家和临床医生的合作，在流体动力学，天然气运输以及诊断和治疗性超声波方面具有专业知识。拟议的研究是开发这种潜在革命性技术的重要第一步。