Direction Sensitive Sensor

方向敏感传感器

基本信息

批准号：
6951851
负责人：
CHRISTOS EURIPIDES CONSTANTINOU
金额：
$ 16.01万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2006-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6951851
关键词：
bioengineering /biomedical engineering biomechanics biosensor device clinical research human subject monitoring device pelvis technology /technique development urethra urinary bladder urinary incontinence urination urology vagina

项目摘要

DESCRIPTION (provided by applicant): The focus of the present application is to develop a new in vivo sensor and associated instrumentation to enable the intraluminal monitoring of tissue characteristics. The design specifications incorporate a directionally sensitive sensor probe capable of evaluating tissue compliance, displacement contact pressure and force of contraction. This instrument will be used to assess the static and dynamic biomechanical characteristic of the vagina and its response to active voluntary pelvic floor contractions and passive compression produced by Valsalva. Movement of the vagina can be displayed instantly on the monitor to provide feedback to the patient. This sensor system can be useful in resolving the cause of female urinary incontinence, which affects up to 35% of adult population by enhancing the value of the physical examination and supplementing urodynamic tests. While useful in the evaluation of bladder/urethral function, urodynamics does not provide relevant information on the influence of the pelvic floor, in maintaining continence. Indeed appropriate evaluation of pelvic floor function is critical in determining whether conservative management, such as strengthening with Kegel exercises, can be useful for treatment. We propose to introduce forthwith a novel in vivo sensor that will enable the quantitative testing of pelvic floor function in a manner corresponding to urodynamics. The design specifications of this instrument are based upon knowledge acquired from imaging, physical examination and urodynamics. We anticipate that this probe will be fabricated so that it can be handled readily by medical personnel with the minimum of training. We expect that this probe will by used by urologists, gynecologists and physical therapists in association with urodynamic testing or independently. We intend to build a prototype probe, write associated software for data collection, evaluation and calibration of transducers and identify frequency response parameters followed by a few pilot studies to obtain data from human subjects with varying etiology of urinary continence.

描述（由申请人提供）：本应用的重点是开发一种新的体内传感器和相关的仪器，以实现组织特征的腔内监测。设计规范包含了一个方向敏感的传感器探针，能够评估组织依从性，位移接触压力和收缩力。该仪器将用于评估阴道的静态和动态生物力学特征及其对瓦尔萨尔瓦（Valsalva）产生的活性自愿骨盆底收缩和被动压缩的反应。阴道的运动可以立即显示在监视器上，以向患者提供反馈。该传感器系统可用于解决女性尿失禁的原因，这通过增强体格检查的价值和补充尿动力学测试，从而影响了35％的成人人群。虽然在评估膀胱/尿道功能的评估中有用，但尿动力学并未提供有关骨盆底影响和维持持续性影响的相关信息。确实，对骨盆底功能的适当评估对于确定保守管理（例如通过凯格尔练习加强）是否对治疗有用。我们建议立即引入一种新颖的体内传感器，该传感器将以与尿动力学相对应的方式对骨盆底功能进行定量测试。该仪器的设计规范基于从成像，身体检查和尿动力学获得的知识。我们预计将对此探测进行制造，以便由最少培训的医务人员轻松处理。我们预计，泌尿科医生，妇科医生和物理治疗师将使用与尿动力学测试或独立的泌尿科医生和物理治疗师使用的调查。我们打算构建一个原型探针，为数据收集编写相关软件，评估和校准换能器，并确定频率响应参数，然后进行一些初步研究，以获取来自人类受试者的数据，该受试者具有不同的尿传感病因。