Breast Cancer Program

乳腺癌计划

• 批准号: 7069878
• 负责人: SAMUEL C BROOKS
• 金额: $ 1.02万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7069878
• 关键词: antineoplastics; biological signal transduction; breast neoplasm /cancer diagnosis; breast neoplasms; cancer prevention; cell growth regulation; estrogen receptors; hormone related neoplasm /cancer; human subject; laboratory mouse; molecular oncology; neoplasm /cancer chemotherapy; neoplasm /cancer epidemiology; neoplasm /cancer genetics; neoplasm /cancer immunotherapy; neoplasm /cancer pharmacology; neoplasm /cancer therapy; neoplasm /cancer vaccine; neoplastic process; nutrition aspect of cancer; nutrition related tag; patient oriented research; preneoplastic state; protein structure function; steroid hormone

The Breast Cancer is and comprehensive, spanning basic and translational research. Program integrated The focus of this program is the study of the mechanims involved in tumor progression and growth. Utilizing the MCF10 model of human preneoplastic, proliferative disease, members of this program are able to examine the genetic factors involved in early breast cancer development, atypical hyperplasia, carcinoma in situ and the progression to invasive cancer. Translational research employs this model as a preclinical test system for preventive agents and strategies. Basic research is also dedicated to understanding the mechanism of growth promoting cell signaling in breast cells, as well as aberations in signaling during neoplastic transformation and in resistance to hormonal and chemotherapy. These studies extend to the examination of the relationship of the structure of the estrogen receptor (ER) to its function, the influence of ER second messenger cross talk and the control of proliferation/apoptosis. In addition, new concepts involving Her-2 DNA vaccines are being explored as a means of immunological control of tumor growth. Mechanisms involved in the sensitivity/resistance of breast tumors to agents controlling growth are being examined. Joint studies with other programs are being carried out to improve dietary intervention in breast cancer prevention, examine the effect of chemopreventive agents on gene expression in preinvasive breast cancer cells and development of a serum based early detection assay for breast cancer. A better understanding of the population genetics of breast cancer in African American women is being sought as welI as further elucidation of the role of the X-chromosome in this disease. Results from basic research have led to clinical protocols to test the ameliorating effect of genistein on chemotherapy, the role of heparanase in metastasis and the development of molecular strategies for early assessment of tumor injury.

乳腺癌是全面的，涵盖了基础和转化研究。该程序集成了该程序的重​​点是研究肿瘤进展和生长的机械。该计划的成员利用人类前塑性，增生性疾病的MCF10模型能够检查早期乳腺癌发展，非典型增生，原位癌和侵入性癌症的遗传因素。转化研究将该模型用作预防剂和策略的临床前测试系统。基础研究也致力于理解 促进乳腺细胞中细胞信号的生长机制，以及在肿瘤转化期间以及对激素和化学疗法的抗性期间信号传导中的原始机制。这些研究扩展到雌激素受体（ER）与其功能的结构的关系，ER第二信使交叉讲座的影响以及对增殖/凋亡的控制。此外，正在探索涉及HER-2 DNA疫苗的新概念，作为对肿瘤生长的免疫控制的一种手段。正在研究乳腺肿瘤对控制生长的药物的敏感性/抗性的机制。正在与其他程序进行联合研究，以改善乳房的饮食干预 预防癌症，检查化学预防剂对侵染前乳腺癌细胞中基因表达的影响，并开发基于血清的乳腺癌早期检测测定法。对非裔美国妇女乳腺癌的种群遗传学的更好理解，就像对X染色体在这种疾病中的作用的进一步阐明一样。基础研究的结果导致了临床方案，以测试染料木黄酮对化学疗法的改善作用，肝素酶在转移中的作用以及分子策略的发展以早期评估肿瘤损伤。