Eye Position Effects in Auditory Cortex

听觉皮层中眼睛位置的影响

• 批准号: 6779880
• 负责人: KRISTIN KELLY PORTER
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6779880
• 关键词: Macaca mulatta; acoustic nerve; auditory cortex; auditory stimulus; behavioral /social science research tag; biological signal transduction; cognition; computational neuroscience; electrophysiology; eye movements; histology; inferior colliculus; learning; magnetic resonance imaging; mathematical model; microelectrodes; neural information processing; neurons; neuropsychology; oculomotor nerve; sensorimotor system; sound perception; visual cortex; visual stimulus

DESCRIPTION (provided by applicant): The long-term objective of this proposal is to understand how the brain compares and combines information gathered by the different sensory systems. Historically, sensory pathways in the brain have been regarded as separate entities, each performing its specific role in parallel, with communication between these different pathways reserved for higher-level association areas. However, modulation of auditory responses by eye position has been observed as early as the inferior colliculus in the auditory pathway. Eye position also modulates the response to acoustic stimuli in the auditory cortex, suggesting that the different pathways influence each other even at the early stages of processing. The modulation of auditory areas by eye position is likely involved in coordinate transformations necessary for producing a common frame of reference. The experiments in this proposal will elucidate the computational and behavioral features of the eye position signal present in the auditory cortex of awake, behaving primates using electrophysiological recordings. Specifically, the experiments will address how eye movement-based sound localization alters the influence of eye position on auditory responses, the shape of the eye position signal, and how eye position and auditory signals interact to govern the responses of neurons in the auditory cortex. Understanding the interaction between eye position and auditory responses will advance our comprehension of the neural mechanisms underlying multisensory integration, contributing to the development of therapeutic strategies for individuals with sensorimotor impairments.

描述（由申请人提供）：该提案的长期目标是了解大脑如何比较和结合不同感觉系统收集的信息。从历史上看，大脑中的感觉途径被认为是独立的实体，每个实体在同行中扮演其特定作用，并且这些不同的途径在为高级关联区域保留的这些不同的途径之间。但是，在听觉途径中，已经观察到了眼睛位置对听觉反应的调节。眼睛位置还调节听觉皮层中对声学刺激的反应，表明即使在加工的早期阶段，不同的途径也相互影响。通过眼睛位置对听觉区域的调节可能涉及产生常见参考框架所需的坐标转换。该提案中的实验将阐明醒目皮层中存在的眼睛位置信号的计算和行为特征，并使用电生理记录来表现灵长类动物。具体而言，实验将解决基于眼动的声音定位如何改变眼睛位置对听觉反应的影响，眼睛位置信号的形状以及眼睛位置和听觉信号如何相互作用以控制听觉皮层中神经元的反应。了解眼睛位置和听觉反应之间的相互作用将提高我们对多感觉整合基础的神经机制的理解，这有助于为具有感觉型障碍的个体的治疗策略发展。