The Iowa Resuscitation Network:A Rural Regional Clin Ctr

爱荷华州复苏网络：农村地区临床中心

• 批准号: 6941213
• 负责人: RICHARD E KERBER
• 金额: $ 49.39万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941213
• 关键词: brain injury; cardiopulmonary resuscitation; clinical research; clinical trial phase III; cooperative study; emergency health services; health services research tag; heart arrest; human subject; human therapy evaluation; hypotension; intravenous administration; patient oriented research; respiratory therapy; rural area; saline

DESCRIPTION (provided by applicant): This is an application for a Regional Clinical Center which will participate in a Clinical Research Consortium to improve resuscitation outcomes. The overall aim of the consortium is to conduct clinical research in primary cardiopulmonary arrest and in traumatic injury leading to or threatening cardiopulmonary collapse. In this application we address two areas where present resuscitation practices are inadequate: 1) establishing and securing an emergency airway during cardiopulmonary arrest and 2) treatment of traumatic brain injuries with hypotension. We propose two hypotheses which will be tested in randomized controlled clinical trials in prehospital cardiac arrest/head injuries: 1) a new emergency airway, the laryngeal tube airway, will be easier to insert successfully in prehospital cardiac arrest than the endotracheal tube, and will provide ventilatory capability equivalent to the endotracheal tube. 2) Intravenous administration of 7.5% (hypertonic) saline to patients with traumatic brain injuries and hypotension will result in lower intracranial pressures, improved initial Glasgow coma scores on arrival at the emergency department and improved survival with less neurologic damage. If our hypotheses are correct, the emergency treatment of cardiac arrest and traumatic brain injury patients will be significantly more effective, with fewer deaths and less long-term disability.

描述（由申请人提供）： 这是区域临床中心的申请，该中心将参与临床研究联盟以改善复苏结果。 该联盟的总体目标是对原发性心肺骤停和导致或威胁心肺衰竭的创伤性损伤进行临床研究。 在此应用中，我们解决了当前复苏实践不足的两个领域：1）在心肺骤停期间建立和确保紧急气道；2）治疗伴有低血压的创伤性脑损伤。 我们提出了两个假设，将在院前心脏骤停/头部损伤的随机对照临床试验中进行测试：1）一种新的紧急气道，即喉管气道，将比气管插管更容易在院前心脏骤停中成功插入，并且将提供相当于气管插管的通气能力。 2) 对脑外伤合并低血压的患者静脉注射 7.5%（高渗）生理盐水将导致颅内压降低，改善到达急诊科时的初始格拉斯哥昏迷评分，并在减少神经损伤的情况下提高生存率。如果我们的假设是正确的，心脏骤停和创伤性脑损伤患者的紧急治疗将显着更加有效，死亡人数和长期残疾率都会减少。