Epidemiology of Glycemia Inflammation & Cognition

血糖炎症的流行病学

• 批准号: 6983770
• 负责人: Rachel A Whitmer
• 金额: $ 13.56万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6983770
• 关键词: Hispanic Americans; acute phase protein; biomarker; blood glucose; clinical research; cognition; cognition disorders; dementia; disease /disorder proneness /risk; epidemiology; gender difference; glucose tolerance; human data; human old age (65+); hyperglycemia; inflammation; insulin sensitivity /resistance; noninsulin dependent diabetes mellitus; plasminogen activator; postmenopause; short term memory; tumor necrosis factor alpha

This application is for a KOI Mentored Research Scientist Development Award through which the candidate will learn how type 2 diabetes, glucose disorders, arid inflammation contribute to cognitive decline and dementia. The overall goal of this proposal will be to determine whether levels of glycemia and insulinemia are predictive of cognitive decline across the entire range of glucose tolerance and across different ethnic groups. Furthermore, whether differences in inflammation explain predictive associations between glycemia and cognitive performance will be examined. Within the research plan, this goal will be achieved though conducting three prospective studies. The following are the specific aims: 1). To determine the association of measures of glycemia and insulinemia with cognitive functioning. 2). To determine if the association of type 2 diabetes, markers of glycemia and insulinemia, with cognition is mediated by levels of inflammation including c reactive protein, tumor necrosis factor alpha-1, interleukin-6, and plasminogen activator-1. 3). To determine how longitudinal changes in glycemia and insulinemia are associated with cognitive impairment. 4). To determine how glycated hemoglobin is associated with risk of incident dementia, Alzheimer's disease and vascular dementia in patients with Type 2 diabetes. A multidisciplinary team of established senior investigators, each with a different area of expertise and training including diabetes, neurology and epidemiology, has been formed to mentor the candidate on the research and career development plan proposed. The training component of the career plan includes the skills gleaned from the research plan as well as an impressive array of structured activities including formal coursework in diabetes, inflammation and endocrinology, participation in several seminar series on diabetes and dementia, additional collaborations with a biostatistician and geriatrician, regular mentoring interactions; and attendance/presentation at several scientific meetings. The candidate has proposed three studies which seek to gain new knowledge about glycemic and inflammatory risk factors for cognitive impairment in multiethnic cohorts. The expected results should provide new and clinically useful information regarding the influences of glycemic control and glucose disorders on neurocognitive functioning. The proposed KOI application includes an excellent research environment including resources specific to the goals of the training plan, an established team of mentors and, an important research question. The support from the Mentored Scientist Career Award will enable the candidate to make the transition to an independent investigator in the area of glycemia and cognition including establishing an extramurally funded research program.

该申请旨在申请 KOI 指导研究科学家发展奖，通过该奖，候选人将了解 2 型糖尿病、血糖异常、干旱炎症如何导致认知能力下降和痴呆。该提案的总体目标是确定血糖和胰岛素血症水平是否可以预测整个糖耐量范围和不同种族群体的认知能力下降。此外，还将检查炎症差异是否可以解释血糖与认知能力之间的预测关联。在研究计划中，这一目标将通过开展三项前瞻性研究来实现。具体目标如下： 1）。确定血糖和胰岛素血症测量值与认知功能的关联。 2）。旨在确定 2 型糖尿病、血糖和胰岛素血症标志物与认知的关联是否是由炎症水平介导的，包括 C 反应蛋白、肿瘤坏死因子 α-1、白介素-6 和纤溶酶原激活剂-1。 3）。确定血糖和胰岛素血症的纵向变化如何与认知障碍相关。 4）。确定糖化血红蛋白与 2 型糖尿病患者发生痴呆、阿尔茨海默病和血管性痴呆的风险之间的关系。 已经成立了一个由资深研究人员组成的多学科团队，每个人都具有不同领域的专业知识和培训，包括糖尿病、神经病学和流行病学，以指导候选人提出的研究和职业发展计划。职业计划的培训部分包括从研究计划中收集的技能以及一系列令人印象深刻的结构化活动，包括糖尿病、炎症和内分泌学的正式课程，参加关于糖尿病和痴呆症的多个研讨会系列，与生物统计学家的额外合作以及老年病学家，定期指导互动；以及出席/在一些科学会议上发表演讲。该候选人提出了三项研究，旨在获得有关多种族人群认知障碍的血糖和炎症危险因素的新知识。预期结果应提供新的和 有关血糖控制和血糖紊乱对神经认知功能影响的临床有用信息。拟议的 KOI 应用程序包括一个优秀的研究环境，包括特定于培训计划目标的资源、一个既定的导师团队以及一个重要的研究问题。导师科学家职业奖的支持将使候选人能够过渡到该领域的独立调查员 血糖和认知领域，包括建立一个校外资助的研究项目。