Gastrointestinal Biopsychosocial Research Center

胃肠生物心理社会研究中心

• 批准号: 6953598
• 负责人: WILLIAM E WHITEHEAD
• 金额: $ 88.93万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6953598
• 关键词: antidepressants; biofeedback; clinical research; clinical trials; cognitive behavior therapy; comorbidity; constipation; epidemiology; family genetics; fecal incontinence; gastrointestinal disorder; gastrointestinal disorder chemotherapy; generation difference; health education; hormone regulation /control mechanism; human therapy evaluation; hypnosis; irritable bowel syndrome; neuroimaging; pain; pathologic process; psychosomatic disorders; sex hormones; social psychology; stress; violence

DESCRIPTION (provided by applicant): This R24 application requests infrastructure support to establish a Gastrointestinal Biopsychosocial (mind-body) Research Center. The investigators have a longstanding record of NIH-funded research on the pathophysiology and treatment of functional GI disorders including irritable bowel syndrome, fecal incontinence, and pelvic floor dyssynergia. These are prevalent disorders-- 15% for irritable bowel, 2-7% for fecal incontinence, and approximately 2% for pelvic floor dyssynergia--that greatly impair quality of life and result in aggregate health care costs exceeding $25 billion annually. Center research themes on the pathophysiology of irritable bowel include the role of visceral pain perception and its modulation by cognitive and psychological processes, neuroimaging studies of central nervous system mechanisms modulating visceral pain, effects of reproductive hormones on irritable bowel symptoms, the role of stress, abuse history, and other psychosocial factors on clinical outcomes, intergenerational transmission of irritable bowel through heredity and social learning, and excess comorbidity of irritable bowel with other somatic disorders. Clinical trial research includes evaluation of cognitive behavior therapy, hypnosis, antidepressants, and patient education for irritable bowel, and biofeedback for fecal incontinence and constipation. Support is requested for the following cores: (1) Administrative core. (2) Research core consisting of study coordinators and full-time recruiter. (3) Research network of institutions that carry out multicenter studies jointly with the investigators (Mayo Clinic, University of Washington, University of Toronto). (4) Data technology core that provides scannable paper and internet-administered questionnaires, automated telephone systems for data acquisition, and intemet software for tracking enrollment and managing rnulticenter studies. (5) Biometry core providing biostatistical support and data management. (6) Seed grant core providing funding for 4 pilot projects by young investigators annually. (7) Education/ dissemination core to disseminate research findings through a Center newsletter and website. We also request support to recruit a new faculty member with expertise in post-infectious irritable bowel. The proposed Center is university wide and includes investigators from psychology, psychiatry, surgery (gynecology division), neuroradiology, dentistry, and the school of public health.

描述（由申请人提供）：此R24申请要求基础架构支持建立胃肠道生物心理社会（思维）研究中心。研究人员在NIH资助的有关功能性GI疾病的病理生理学和治疗方面有长期记录，包括肠易激综合征，粪便失禁和骨盆底发病障碍。这些是普遍存在的疾病 - 肠易激的15％，粪便失禁的2-7％，骨盆底发症患者的大约2％，这极大地损害了生活质量，并导致每年超过250亿美元的医疗保健费用。中心研究肠易激病理学的主题包括内脏疼痛感知的作用及其通过认知和心理过程调节的作用，对中枢神经系统机制的神经影像学研究，对内脏疼痛进行调节，生殖激素对繁殖激素的影响，可riririble骨症状对肠症状的影响，通过压力，滥用病史和其他临床性bor的影响，对临床的传播，临床的影响，造成的临床bor骨，分类的，分类，分类，使得，分类的bor脉，使得脑部的传播，造成了术语。肠易激的肠易激和其他体细胞疾病的合并症过剩。临床试验研究包括评估认知行为疗法，催眠，抗抑郁药和患者肠易激的教育以及粪便尿失禁和便秘的生物反馈。请求支持以下内核：（1）管理核心。 （2）由研究协调员和全职招聘人员组成的研究核心。 （3）与研究人员共同进行多中心研究的机构研究网络（多伦多大学华盛顿大学梅奥诊所）。 （4）提供可扫描的纸张和互联网管理问卷，用于数据获取的自动电话系统以及用于跟踪注册和管理Rnulticenter研究的Intemet软件的数据技术核心。 （5）提供生物统计支持和数据管理的生物特征核心。 （6）种子赠款核心每年为年轻调查人员提供4个试点项目的资金。 （7）通过中心通讯和网站传播研究结果的教育/传播核心。我们还请求支持，以招募一名新的教职员工，具有肠后易怒的专业知识。拟议的中心是大学范围的，包括心理学，精神病学，外科科（妇科科），神经放射学，牙科和公共卫生学院的研究人员。