Regulation of Prostacyclin in Pulmonary Hypertension

前列环素在肺动脉高压中的调节

• 批准号: 6933068
• 负责人: SERGE PATRICK NANASINKAM
• 金额: $ 13.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933068
• 关键词: biological models; biological signal transduction; cardiovascular pharmacology; clinical research; enzyme linked immunosorbent assay; gene expression; genetic polymorphism; genetic promoter element; genetic regulation; genetic susceptibility; genetic transcription; genetically modified animals; hemodynamics; human subject; hypoxia; laboratory mouse; model design /development; muscle cells; oxidoreductase; platelet derived growth factor; prostacyclins; pulmonary hypertension; regeneration; vascular endothelial growth factors; vascular smooth muscle

DESCRIPTION (provided by applicant): Candidate: The candidate, Patrick Nana-Sinkam, M.D., is an Instructor in the Division of Pulmonary Sciences and Critical Care Medicine at the University of Colorado Health Sciences Center. He is currently supported by an NIH minority supplement grant to the parent grant NIH E PATHO. PROJ IV 5P01 HL066254-03S1, "Prostacyclin Synthase and Prostacyclin Receptor in Severe Pulmonary Hypertension." Dr. Nana-Sinkam has previously worked on transgenic murine models of disease and has developed a particular interest in the eicosanoid pathway and its role in disease susceptibility as well as identifying products with clinical application. His short-term goal is to continue to develop both the professional and research skills to eventually become an independent investigator. Long term, Dr. Nana-Sinkam hopes to develop a successful, independently funded laboratory in eicosanoid biology. This proposed Mentored Clinical Scientist Award would provide him with the support to develop these skills. Career Development: Dr. Nana-Sinkam's career development will include: 1) developing new research skills such as the development of transgenic animal models, research design and professional skills necessary in an academic center, 2) formal educational activities including courses in molecular biology techniques and grant writing, and 3) involvement in administrative activities essential to developing professional skills such as serving on the School of Medicine's Admission and Scholarship Committees and Ethnic Minority Affairs Committee. Environment: Dr. Nana-Sinkam is currently in an environment that is conducive to excellent research. His sponsor, Dr. Mark Geraci, and co-sponsors, Drs. Norbert Voelkel and Raphael Nemenoff, are outstanding, extramurally funded, independent investigators with established records in research. Research: Dr. Nana-Sinkam's general goals will be to attempt to elucidate the mechanisms by which prostacyclin prevent vascular remodeling and are regulated in pulmonary hypertension. The hypotheses will be that 1) the development of a conditional transgenic murine model for overexpression of prostacyclin synthase can assist in defining the temporal relationship between gene expression and remodeling, 2) key regulators of gene transcription involved in suppression of prostacyclin in pulmonary hypertension can be identified by a model for gene transcriptional regulation, and 3) prostacyclin synthease gene polymorphisms exist in defined human populations and have a potential impact on gene function and subsequent susceptibility to disease.

描述（由申请人提供）： 候选人：候选人，医学博士Patrick Nana-Sinkam，是科罗拉多大学健康科学中心肺科学和重症监护医学的讲师。 目前，他得到了NIH少数族裔补充赠款的支持。 ProJ IV 5P01 HL066254-03S1，“严重肺动脉高压中的前列环素合酶和前列环素受体”。 Nana-Sinkam博士以前曾从事过转基因鼠类疾病模型，并且对eicosanoid途径及其在疾病易感性中的作用以及鉴定具有临床应用的产品特别感兴趣。 他的短期目标是继续发展专业和研究技能，最终成为独立的研究者。 长期，Nana-Sinkam博士希望开发一个成功的，独立的类花生类生物学实验室。 这项拟议的指导临床科学家奖将为他提供发展这些技能的支持。 职业发展：Nana-Sinkam博士的职业发展将包括：1）发展新的研究技能，例如开发转基因动物模型，研究设计和学术中心所需的专业技能，2）正式的教育活动，包括分子生物学技术和授予写作课程，以及3）参与行政活动，涉及医学委员会的专业技能必不可少的行政活动，例如在医学学院委员会和学术委员会委员会委员和委员会。 环境：Nana-Sinkam博士目前处于有利于出色研究的环境中。 他的赞助商马克·格拉西（Mark Geraci）博士和共同发起人，博士。 Norbert Voelkel和Raphael Nemenoff是杰出的，具有诸如研究的独立研究人员，具有既定记录。 研究：Nana-Sinkam博士的一般目标将是试图阐明前列环蛋白预防血管重塑的机制，并在肺动脉高压中受到调节。 The hypotheses will be that 1) the development of a conditional transgenic murine model for overexpression of prostacyclin synthase can assist in defining the temporal relationship between gene expression and remodeling, 2) key regulators of gene transcription involved in suppression of prostacyclin in pulmonary hypertension can be identified by a model for gene transcriptional regulation, and 3) prostacyclin synthease gene polymorphisms exist在确定的人群中，对基因功能和随后对疾病的敏感性有潜在的影响。