Air Disinfection Interventions in Grade Schools

小学空气消毒干预措施

• 批准号: 7093523
• 负责人: Maria Patricia Fabian
• 金额: $ 2.94万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-23 至 2007-08-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7093523
• 关键词: air filtration; air pollution; air pollution control; air sampling /monitoring; air treatment; airborne allergen; asthma; biotransformation; clinical research; communicable disease transmission; disease /disorder proneness /risk; elementary school; environmental exposure; health care service utilization; human data; human subject; outcomes research; pediatrics; photobiology; pollution related respiratory disorder; predoctoral investigator; respiratory infections; rhinovirus; ultraviolet radiation

DESCRIPTION (provided by applicant): The role of upper respiratory infections in causing asthma exacerbations is well documented, and accounts for approximately 80% of childhood asthma exacerbations and hospitalizations. Rhinoviruses are the major implicated pathogens. A significant body of evidence suggests that schools are an important site of transmission of respiratory infections but little effort has gone into finding methods to decrease infectious disease transmission. The objectives of this crossover intervention study are to determine the effectiveness of three air disinfection techniques in reducing grade school children's asthma attack rates, visits to the nurse and absence rates due to respiratory infections. Upper-room ultraviolet lights, photocatalytic oxidation devices and high-efficiency filters will be installed in classrooms at a grade school in Connecticut. Airborne rhinovirus concentrations will be collected and monitored throughout the school year and analyzed using quantitative PCR methods. Absence data will be collected from the school database, and nurse's visits from the school nurse's log. Data will be modeled using advanced logistic regression models to determine effectiveness of interventions.

描述（由申请人提供）：充分记录了上呼吸道感染在引起哮喘加重的作用，约占儿童哮喘患病和住院的80％。鼻病毒是主要的病原体。大量证据表明，学校是呼吸道感染传播的重要地点，但在寻找减少传染病传播的方法上几乎没有努力。这项跨界干预研究的目标是确定三种空气消毒技术在降低小学生哮喘攻击率，拜访护士和由于呼吸道感染引起的缺勤率方面的有效性。康涅狄格州一所小学的教室将安装上室紫外线，光催化氧化设备和高效过滤器。在整个学年中，将收集和监测空气中的鼻病毒浓度，并使用定量PCR方法进行分析。缺席数据将从学校数据库中收集，并从学校护士的日志中访问。数据将使用先进的逻辑回归模型对数据进行建模，以确定干预措施的有效性。

项目成果

Airborne influenza virus detection with four aerosol samplers using molecular and infectivity assays: considerations for a new infectious virus aerosol sampler.

• DOI: 10.1111/j.1600-0668.2009.00609.x
• 发表时间: 2009-10
• 期刊: Indoor air
• 影响因子: 5.8
• 作者: Fabian P;McDevitt JJ;Houseman EA;Milton DK
• 通讯作者: Milton DK

An optimized method to detect influenza virus and human rhinovirus from exhaled breath and the airborne environment.

• DOI: 10.1039/b813520g
• 发表时间: 2009-02
• 期刊: Journal of environmental monitoring : JEM
• 作者: Fabian P;McDevitt JJ;Lee WM;Houseman EA;Milton DK
• 通讯作者: Milton DK