Frontal-Cerebellar Development Assessed with MRI & fMRI

通过 MRI 评估额叶小脑发育

• 批准号: 7158206
• 负责人: ELIZABETH Doyle O'HARE
• 金额: $ 2.97万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7158206
• 关键词: adolescence (12-20); auditory stimulus; behavior test; behavioral /social science research tag; brain morphology; cerebellar cortex; child psychology; clinical research; computer program /software; developmental neurobiology; fetal alcohol syndrome; functional magnetic resonance imaging; gray matter; human subject; middle childhood (6-11); predoctoral investigator; prefrontal lobe /cortex; short term memory; visual stimulus

DESCRIPTION (provided by applicant): The proposed studies aim to combine functional and structural MRI methodology to examine relationships between structural development and functional maturation in the frontal-cerebellar system, in both normally developing children and adolescents and those with histories of prental alcohol exposure (ALC). High resolution MRI coupled with surface-based computational algorithms will be used to measure grey matter thickness in frontal cortex and localized radial expansion of the cerebellar cortex. Correlational analyses will quantify the relationship between these structural features and functional activation during a verbal working memory task at every cortical surface point within the frontal and cerebellar corticies. These studies will further our understanding of the structural and functional changes in the cerebellum that result from prenatal exposure to alcohol. In addition, these studies represent a first attempt at (1) characterizing the structural maturation of the cerebellum, (2) relating cerebellar development to that of the frontal cortex, and (3) interrogating how structural differences in these regions impact functional activation on a frontal-cerebllar working memory task.

描述（由申请人提供）：拟议的研究旨在结合功能性和结构性 MRI 方法来检查正常发育的儿童和青少年以及有产前酒精暴露史的儿童和青少年的额叶小脑系统的结构发育和功能成熟之间的关系（ ALC）。高分辨率 MRI 与基于表面的计算算法相结合将用于测量额叶皮层的灰质厚度和小脑皮层的局部径向扩张。相关分析将量化额叶和小脑皮质内每个皮质表面点的言语工作记忆任务期间这些结构特征和功能激活之间的关系。这些研究将进一步加深我们对产前接触酒精导致的小脑结构和功能变化的理解。此外，这些研究首次尝试（1）表征小脑的结构成熟，（2）将小脑发育与额叶皮层的发育联系起来，以及（3）探讨这些区域的结构差异如何影响大脑功能激活。额叶-小脑工作记忆任务。