LV Volume Determinations: Mouse to Clinical Applications

左心室容量测定：小鼠临床应用

• 批准号: 6989659
• 负责人: Judith K Gwathmey
• 金额: $ 28.66万
• 依托单位: GWATHMEY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989659
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; computer program /software; computer system design /evaluation; heart conduction system; heart dimension /size; heart electrical activity; heart ventricle; intracardiac volume; laboratory mouse; myocardium

DESCRIPTION (provided by applicant): Determination of accurate instantaneous left ventricle (LV) volume is an important tool in drug and device discovery for congestive heart failure. First generation conductance instruments generate as instantaneous conductance (volume) signal composed of blood and myocardium even at a single low frequency. However, only the blood component is desired. Classic methods used to assess the hemodynamic phenotype in mammals are through LV pressure - volume relations. Due to the small size of the mouse heart and fast heart rate determining absolute and instantaneous volume of the LV has not been possible. We propose a mechanism to overcome this limitation. Complex Conductance (Admittance) measures both the magnitude of LV blood and myocardial conductance, as well as the phase angle of myocardial conductance. We propose that Complex Conductance offers a better method to determine and remove the instantaneous myocardial contribution to LV blood volume determinations. Our GOALS are to create a Complex Conductance Instrument that reports instantaneous LV volume that is accurate and reliable. The instrument will allow for the first time between animal comparisons as well as between patient comparisons. Our device will be compared during Phase 2 studies with traditional conductance instruments as well as MRI, the gold standard for static derivation of LV volume. Long term we plan to commercialize our devices to three markets 1) as a telemetered system in mice; 2) for use in larger animals both telemetered and non-telemetered e.g. dog, pig, sheep, and primates; and 3) for clinical use by physicians to determine whether new medications and surgical procedures are primarily increasing myocardial contractility or reducing preload and afterload in patients with congestive heart failure. Our SPECIFIC AIM is to develop an instrument and algorithms to derive instantaneous LV volume from Complex Conductance (Admittance) measurements.

描述（由申请人提供）：确定准确的瞬时左心室（LV）体积是用于充血性心力衰竭的药物和设备发现的重要工具。第一代电导仪器作为瞬时电导（体积）信号即使在单个低频下也是由血液和心肌组成的信号。但是，只需要血液成分。用于评估哺乳动物血流动力学表型的经典方法是通过LV压力 - 体积关系。由于小鼠心脏的尺寸较小，并且无法确定LV的绝对和瞬时体积的快速心率。我们提出了一种克服这一限制的机制。复杂的电导（入学）测量LV血液和心肌电导的大小以及心肌电导的相角。我们建议复杂的电导提供了一种更好的方法来确定和去除对LV血量测定的瞬时心肌贡献。我们的目标是创建一种复杂的电导工具，该工具报告了准确可靠的瞬时LV量。该仪器将在动物比较以及患者比较之间首次允许。在2阶段研究期间，我们的设备将与传统电导仪器以及MRI（LV体积静态推导的黄金标准）进行比较。长期，我们计划将我们的设备商业化到三个市场1）作为小鼠的遥测系统； 2）用于大型动物，远距离和非污染的动物，例如狗，猪，绵羊和灵长类动物； 3）医生的临床使用来确定新药物和外科手术是否主要增加心肌收缩力或减少充血性心力衰竭患者的预紧和后负荷。我们的具体目的是开发一种仪器和算法，以从复杂电导（入学）测量中得出瞬时的LV体积。