Miniature Real-Time Volumetric Ultrasound Imaging System

微型实时体积超声成像系统

• 批准号: 6927188
• 负责人: BUTRUS T KHURI-YAKUB
• 金额: $ 46.22万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-02 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6927188
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; clinical research; endoscopy; human subject; human therapy evaluation; imaging /visualization /scanning; neoplasm /cancer therapy; three dimensional imaging /topography; ultrasonography; ultrasound therapy

DESCRIPTION (provided by applicant): We propose to develop a miniature real-time volumetric ultrasound imaging system employing two-dimensional (2D) capacitive micromachined ultrasonic transducer (CMUT) arrays. We will design and implement a miniature probe fitting into the tip of an endoscope that will be connected to an external beamforming unit using a small number of cables. The probe will contain a 2D CMUT array and integrated circuits to handle the data acquisition and front-end pre-processing. A small-sized active phased subarray will be multiplexed over a large transducer array in consecutive firing steps to allow for real-time data acquisition. The acquired data will be transferred to the external unit and processed to form real-time pyramidal volumetric images. CMUT technology provides excellent element sensitivity, large temporal bandwidth, and potential for integrating the transducer with front-end electronic circuitry. The image reconstruction algorithm is based on phased subarray processing which allows for a low-cost front-end architecture while providing high-quality real-time images. The combination of CMUT technology and phased subarray (PSA) imaging will enable us to realize a small ultrasound scanner where the size and cost of the front-end circuitry is critical. We have achieved the following preliminary results: (1) Identified several image-guided surgical applications for cancer treatment, (2) specified the probe parameters based on physician input, (3) fabricated 128-element 1D CMUT array and (4) used it to form a high-quality 2D image, (4) fabricated a prototype 16x16-element 2D CMUT array, (5) developed PSA theory for 2D and 3D imaging, (6) tested 2D PSA theory with simulations and experimental data, and (7) shown that the system specs allow for real-time 3D ultrasound imaging. We propose to take the next major developmental step and demonstrate real-time 3D imaging from a miniature probe by accomplishing the following specific aims: (1) form preliminary 3D images using the prototype array and existing acquisition system, (2) design and fabricate new 16x16 2D CMUT arrays, (3) implement real-time beamforming and visualization, (4) design and build integrated circuits for the front-end probe electronics, (5) perform final integration into a fully function real-time 3D ultrasound system, and (6) perform preliminary clinical evaluation.

描述（由申请人提供）： 我们建议使用二维（2D）电容微机械超声传感器（CMUT）阵列开发微型实时体积超声成像系统。我们将使用少量电缆设计和实现拟合内窥镜尖端的微型探针。该探针将包含一个2D CMUT阵列和集成电路，以处理数据采集和前端预处理。一个小型的活动阶段子阵列将以连续的启动步骤在大型传感器阵列上多路复用，以允许实时数据采集。获得的数据将转移到外部单元并进行处理以形成实时金字塔体积图像。 CMUT技术提供了出色的元素灵敏度，较大的时间带宽以及将传感器与前端电子电路集成的潜力。图像重建算法基于分阶段的子阵列处理，该处理允许在提供高质量的实时图像的同时进行低成本的前端体系结构。 CMUT技术和分阶段子阵列（PSA）成像的组合将使我们能够实现一个小型的超声扫描仪，其中前端电路的大小和成本至关重要。 We have achieved the following preliminary results: (1) Identified several image-guided surgical applications for cancer treatment, (2) specified the probe parameters based on physician input, (3) fabricated 128-element 1D CMUT array and (4) used it to form a high-quality 2D image, (4) fabricated a prototype 16x16-element 2D CMUT array, (5) developed PSA theory for 2D和3D成像，（6）通过模拟和实验数据测试了2D PSA理论，并且（7）表明系统规范允许实时3D超声成像。 We propose to take the next major developmental step and demonstrate real-time 3D imaging from a miniature probe by accomplishing the following specific aims: (1) form preliminary 3D images using the prototype array and existing acquisition system, (2) design and fabricate new 16x16 2D CMUT arrays, (3) implement real-time beamforming and visualization, (4) design and build integrated circuits for the front-end probe electronics, （5）最终集成到完全功能的实时3D超声系统中，（6）执行初步临床评估。

项目成果

Wafer-bonded 2-D CMUT arrays incorporating through-wafer trench-isolated interconnects with a supporting frame.

晶圆键合 2-D CMUT 阵列将贯穿晶圆的沟槽隔离互连与支撑框架结合在一起。

• DOI: 10.1109/tuffc.2009.1018
• 发表时间: 2009
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Zhuang,Xuefeng;Wygant,IraO;Lin,Der-Song;Kupnik,Mario;Oralkan,Omer;Khuri-Yakub,ButrusT
• 通讯作者: Khuri-Yakub,ButrusT

Deep tissue photoacoustic imaging using a miniaturized 2-D capacitive micromachined ultrasonic transducer array.

• DOI: 10.1109/tbme.2012.2183593
• 发表时间: 2012-05
• 期刊: IEEE transactions on bio-medical engineering
• 作者: Kothapalli SR;Ma TJ;Vaithilingam S;Oralkan O;Khuri-Yakub BT;Gambhir SS
• 通讯作者: Gambhir SS