PATHOBIOLOGY OF GI INFECTION AND INFLAMATION

胃肠道感染和炎症的病理学

• 批准号: 7015532
• 负责人: MICHAEL D GERSHON
• 金额: $ 4.13万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7015532
• 关键词: PATHOBIOLOGY; GI; INFECTION; INFLAMATION

JJ Principal Investigator/Program Director (Last, first, middle): ^ Gershnn, M.D. DESCRIPTION: State the applicatiorrsDroao^M-ferm objectives and specitic aims, maKing reference lo^BfieaTth relatedness ot the project. Describe concisely the research design and methods for achievinlHIse goals. Avoid summaries of past accomplishments ari^B use of the first person. This description is meant to A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection,have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luban (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and Hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations. serve as a succinct ana accurate description ot the proposed wornwhen separated from the application, it tne application is lunded, this description, as is, will Columbia University, College of Physicians and Surgeons 630 West 168th Street New York, NY 10032 PERFORMANCE SITE ========================================Section End===========================================

JJ首席调查员/计划主管（最后一个，中间，中间）：^Gershnn，M.D。说明：陈述应用程序Applicationatiorrsdroao^m-Ferm目标和特定目标，使参考lo^bfieatth与该项目相关。简洁地描述了成就目标的研究设计和方法。避免摘要过去的成就Ari^b使用第一人称。该描述是指哥伦比亚的一组高级研究人员组，对保护肠子免受微生物感染的机制具有共同的兴趣，它设计了GI感染和炎症培训计划和请求支持。在第1年，在第2年的第1年和4年的第3-5年级前研究员中要求提供2个博士前研究员的资金，3年级的博物馆前研究员。从历史上看，在哥伦比亚，感染基础研究以微生物学系为中心。然而，由于入侵生物有能力利用宿主细胞机制执行其邪恶的生命周期，因此对发病机理的研究越来越多地参与了细胞生物学的研究。同样，微生物学家现在对细胞生物学的关注与带有该名称的部门的成员一样。因此，将学员广泛地暴露于许多学科是现实而重要的。细菌和病毒发病机理提供了一个很棒的多学科训练机会，我们现在提议充分利用它。此外，最好的博物前申请人对疾病的机制感兴趣，并希望将其包括在其培训前训练中。因此，来自4个基本和3个临床科学部门的18位教职员工共同开发了胃肠道感染和炎症的主题，部门跨部门前培训计划。参与的教师包括：Q. al-Awqati（肠道上皮的分化和膜运输）； J. Bulinski（细胞内转运中的微管功能）； M. Field（跨肠上皮膜的离子运输）； M. Gershon（肠神经系统的发展和功能）； A. Gershon（疱疹病毒和艾滋病毒感染）； S. Goff（逆转录病毒感染和复制）； G. Gundersen（膜运输的微管控制）； R. kessin（吞噬作用的机制）； R. Liem（肠神经系统的细胞骨架）； J. Luban（HIV-1复制与发病机理）； A. Mitchell（真菌感染，白色念珠菌）； L. pON（膜运输和肠杆菌感染的肌动蛋白细胞骨架控制）； A.王子（细菌 - 宿主相互作用）； V. racaniello（肠病毒发病机理）； H. Shuman（肠杆菌的发病机理）； S. Silverstein（膜运输和白细胞）；和H. Worman（炎症性肠，肝疾病和肝炎）。该计划的多学科性质与哥伦比亚大学的研究生教育的发展是一致的。它还多年来首次提供了对胃肠道疾病研究和研究培训的机构的关注。该计划的成立已经导致了新的研究生课程的发展，扩展现有课程并建立了新的合作。用作简洁的ana准确描述，即与应用程序分开时所提出的磨损，该申请被阐述，此描述，如哥伦比亚大学，哥伦比亚大学，医师和外科医生学院，纽约州西168街630号，纽约州10032纽约，纽约10032纽约，纽约州纽约州的性能站点=========================================================== end ========================================

项目成果

Large-scale gene disruption using the UAU1 cassette.

• DOI: 10.1007/978-1-60327-151-6_17
• 发表时间: 2009
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Nobile, Clarissa J.;Mitchell, Aaron P.
• 通讯作者: Mitchell, Aaron P.