SYNAPTIC INTEGRATION IN THE ACCESSORY OLFACTORY BULB

附件嗅球中的突触整合

• 批准号: 6867333
• 负责人: Nathan Neal Urban
• 金额: $ 16.4万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6867333
• 关键词: biological signal transduction; calcium indicator; cell cell interaction; cell morphology; chemoreceptors; computational biology; dendrites; electrodes; electrophysiology; fluorescent dye /probe; hormone regulation /control mechanism; laboratory mouse; neural information processing; neurons; olfactory lobe; pheromone; sensory receptors; synapses; tissue /cell culture; voltage /patch clamp

DESCRIPTION (provided by applicant): The long-term goal of this project is to understand how the properties of dendrites and circuits influence the integration of pheromone-evoked activity in the mammalian accessory olfactory system. Integration of synaptic inputs arriving at thousands of sites across the dendritic tree is a basic mechanism that influences the functional properties of all neuronal types. In particular types of neurons the mechanisms of synaptic integration are thought to be highly specialized to process certain types of inputs, for example to detect short time delays in the auditory system. The dendritic trees of accessory olfactory bulb (AOB) mitral cells have a complicated and highly specialized morphology. These cells seem to be designed to sample inputs arriving at multiple locations (glomeruli), and then to convey some information about this activity to the mitral cell soma from which it can be passed on to higher brain areas. We propose to use physiological and computational techniques to improve our understanding of synaptic integration in the cells and circuits of the accessory olfactory bulb. In particular we will examine the influence of active and passive properties of AOB mitral cell dendrites on the propagation of synaptic activity from the tufts to the somata of these cells. We also will examine how inputs to multiple tufts are integrated, and determine how activity at one tuft is influenced by signals arriving at other tufts. Overall the experiments proposed will provide increased understanding of many basic issues of synaptic and dendritic processing in neurons, and in particular they will provide valuable information on the integration of chemosensory information in the accessory olfactory system.

描述（由申请人提供）：该项目的长期目标是了解树突和电路的特性如何影响哺乳动物附件嗅觉系统中信息素诱发活动的整合。在树突树上成千上万个位点到达的突触输入的整合是影响所有神经元类型的功能特性的基本机制。在特定类型的神经元中，突触整合的机制被认为是高度专业的，可以处理某些类型的输入，例如检测听觉系统中的短时间延迟。辅助嗅球（AOB）二尖瓣的树突树具有复杂且高度专业化的形态。这些细胞似乎是为了采样到达多个位置（Glomeruli）的输入，然后将有关此活性的一些信息传达给二尖瓣细胞体，从中可以将其传递到更高的大脑区域。我们建议使用生理和计算技术来提高我们对辅助嗅球细胞和电路中突触整合的理解。特别是，我们将研究AOB二尖瓣树突的主动和被动特性对这些细胞簇的突触活性传播的影响。我们还将研究如何整合到多个簇的输入，并确定一个簇的活动如何受到到达其他簇的信号的影响。总体而言，提出的实验将对神经元中突触和树突加工的许多基本问题提供更多的了解，尤其是它们将提供有关辅助嗅觉系统中化学感觉信息整合的有价值信息。