Does psycholigocal wellness predict treatment response?

心理健康可以预测治疗反应吗？

• 批准号: 6898934
• 负责人: ARTHUR Ian ALTERMAN
• 金额: $ 15.85万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6898934
• 关键词: alcoholism /alcohol abuse therapy; attitude; behavior prediction; behavioral /social science research tag; clinical research; drug abuse therapy; gender difference; human subject; human therapy evaluation; mental disorders; mental health; outpatient care; patient oriented research; psychological models; psychological tests; questionnaires; religion; substance abuse epidemiology; substance abuse related behavior

DESCRIPTION (provided by applicant): This is an R21 application for innovative/developmental research by an experienced substance dependence investigator. The study of psychological characteristics of patients that are predictive of response to substance abuse treatment has largely focused upon negative characteristics such as depression, anxiety, antisocial personality, or hostility, i.e., psychological illness. Although a growing literature has shown that various dimensions of psychological wellness of individuals and patients are associated with positive health outcomes in general, there has been only limited investigation of whether aspects of psychological wellness are also predictive of response to substance abuse treatment. The proposed research is designed to determine whether psychological strengths such as optimism, personal meaning, perceived wellness, spirituality/religiosity, positive mood, or social support are predictive of a more positive response to treatment in 300 substance abuse patients and whether the benefits of these psychological strengths are additive or interactive. Outcomes predicted will be treatment completion and during-treatment cocaine urine toxicologies; and days of cocaine use and heavy alcohol use during study months 4-6. The research further inquires whether the contribution of psychological wellness to the prediction of treatment outcomes is independent of that predicted by psychological illness and includes statistical evaluations for two mediation hypotheses which may help to explain the effects of optimism and spirituality/religiosity. The research will also implement a within- and between-instrument latent structure analysis of the various measures of psychological strengths in order to determine their underlying dimensionality. A number of secondary analyses will be undertaken. These include determination of the predictive validity of salient sociodemographic variables such as gender, evaluation of the predictive validity of psychological wellness for other relevant outcomes (e.g., days of heroin use, psychological and legal status at follow-up; risk for AIDS behaviors), evaluation of the relationships between psychological wellness and illness, and exploratory recursive partitioning analyses which may provide information on complex combinations of predictor variables.

描述（由申请人提供）： 这是经验丰富的物质依赖研究者进行创新/发展研究的R21应用程序。对预测对药物滥用治疗反应的患者的心理特征的研究主要集中在抑郁症，焦虑，反社会人格或敌对的负面特征上，即心理疾病。尽管越来越多的文献表明，个体和患者的心理健康的各个方面与总体上健康结果有关，但对心理健康方面是否还可以预测对药物滥用治疗的反应，只有有限的研究。拟议的研究旨在确定心理优势，例如乐观，个人意义，感知的健康，灵性/宗教信仰，积极的情绪或社会支持是否可以预测300名滥用药物的患者对治疗的更积极反应，以及这些心理优势的好处是加性的还是互动的。预测的结果将是治疗完成和治疗期间可卡因尿液毒理学；以及在研究月4-6的研究期间可卡因使用和大量饮酒的日子。该研究进一步询问心理健康对治疗结果预测的贡献是否与心理疾病预测的预测无关，并包括对两个调解假设的统计评估，这可能有助于解释乐观和灵性/宗教信仰的影响。这项研究还将对心理优势的各种措施进行启发式和仪器之间的潜在结构分析，以确定其潜在的维度。将进行许多二次分析。这些包括确定显着的社会人口统计学变量（例如性别）的预测有效性，对心理健康对其他相关结果的预测有效性的评估（例如，海洛因使用日，随访时的心理和法律状态；辅助行为的风险；对艾滋病行为的风险），对心理和疾病和疾病和探索性恢复性分析的评估的评估，对恢复性分析进行了分析，以进行分析。