ULTRASOUND SYSTEMS FOR SIMULTANEOUS THERMORADIOTHERAPY

用于同步热放射治疗的超声系统

• 批准号: 7121434
• 负责人: Eduardo G. Moros
• 金额: $ 11.49万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121434
• 关键词: biomedical equipment development; breast neoplasms; clinical research; clinical trials; female; human subject; human therapy evaluation; metastasis; neoplasm /cancer relapse /recurrence; neoplasm /cancer thermotherapy; patient care planning; phantom model; portable biomedical equipment; thermometry; women' s health

Our long term goal is to maximize the benefits of hyperthermia by developing systems capable of inducing therapeutic thermal doses in entire tumor volumes (to maximize hyperthermic cytotoxicity) and that allow simultaneous delivery of ionizing radiation (to maximize thermal radiosensitization). This application seeks to translate into the radiotherapy clinic a superficial ultrasound hyperthermia system designed for sequential and simultaneous thermoradiotherapy and to evaluate its performance in a human clinical trial. The system (SURLAS for Scanning Ultrasound Reflector Linear Array System) will be based on device developments, numerical modeling and laboratory studies performed under the current funding period. Simultaneous irradiation using electron beams will be tested clinically for the first time. The specific aims are: (1) Develop a SURLAS suitable for superficial sequential/simultaneous thermoradiotherapy clinical trials with human subjects, compatible with electron/photon beam irradiation, and with 3D heating pattern control. Pre-clinical testing is also part of this aim. (2) Develop a Linac-SURLAS-Patient portable interface to minimize the utilization time of the linear accelerator (linac). The goal is to start the hyperthermia treatment outside the linac room; then midway through the heat treatment the patient and the SURLAS are transported into the room and interfaced with the linac. The radiation fraction is then given without interruption of hyperthermia. The final step is to transport the Linac- SURLAS-Patient portable interface out of the linac room to complete the hyperthermia. (3) Develop a practical hyperthermia treatment planning tool to select initial insonation parameter for the SURLAS depending on target volume characteristics, and to assist the physician in evaluating ultrasound isopower contours with respect to radiation isodoses. We will incorporate ultrasound power deposition distributions into treatment planning tools/programs (CT/MRI-based) developed in our department for 3D radiotherapy. And (4), perform a simultaneous hyperthermia and external beam radiation clinical trial with human patients to: (i) Evaluate the thermal performance of the SURLAS against that of the presently used commercial ultrasound hyperthermia system. (ii) Establish quantitatively, using thermal dosimetry indicators, that heating with the SURLAS is better than with the current device. (iii) Demonstrate that the simultaneous administration o hyperthermia and radiation can be more cost effective by permitting the bulk of the patient's hyperthermia to take place outside the linac room. (iv) Establish feasibility of simultaneous hyperthermia and electron beam radiotherapy. This proposal represents the translation of new hyperthermia technology and decades of biological studies into the human clinic. The benefits to patients e.g., greater likelihood of local tumor control outweigh potential risks.

我们的长期目标是通过开发能够在整个肿瘤体积中诱导治疗热剂量（以最大限度地提高热细胞毒性）并允许同时传递电离辐射（以最大限度地提高热放射增敏作用）的系统来最大限度地发挥热疗的益处。该应用旨在将专为顺序和同步热放射治疗而设计的浅表超声热疗系统转化为放射治疗诊所，并评估其在人体临床试验中的性能。该系统（用于扫描超声反射器线性阵列系统的 SURLAS）将基于当前资助期间进行的设备开发、数值建模和实验室研究。使用电子束的同时照射将首次在临床上进行测试。具体目标是：（1）开发适合人体浅表序贯/同步热放射治疗临床试验的SURLAS，与电子/光子束照射兼容，并具有3D加热模式控制。临床前测试也是这一目标的一部分。 (2)开发Linac-SURLAS-Patient便携式接口，以最大限度地减少直线加速器（linac）的使用时间。目标是在直线加速器室外开始热疗治疗；然后，在热处理过程中，患者和 SURLAS 被运送到房间并与直线加速器连接。然后在不中断热疗的情况下进行放射治疗。最后一步是将 Linac-SURLAS-Patient 便携式接口运出直线加速器室以完成热疗。 (3)开发实用的热疗计划工具，根据靶体积特征选择SURLAS的初始声波参数，并协助医生评估相对于辐射等剂量的超声等功率轮廓。我们将把超声功率沉积分布纳入我们部门开发的 3D 放射治疗治疗计划工具/程序（基于 CT/MRI）中。 (4) 对人类患者进行同步热疗和外束辐射临床试验，以： (i) 对照目前使用的商用超声热疗系统评估 SURLAS 的热性能。 (ii) 使用热剂量测定指标定量地确定，使用 SURLAS 加热比使用当前设备更好。 (iii) 证明通过允许患者的大部分热疗在直线加速器室外进行，同时进行热疗和放射治疗可以更具成本效益。 (iv) 建立同时热疗和电子束放射治疗的可行性。该提案代表了将新的热疗技术和数十年的生物学研究转化为人类临床。对患者的好处（例如，局部肿瘤控制的可能性更大）超过了潜在的风险。

项目成果

Treatment delivery software for a new clinical grade ultrasound system for thermoradiotherapy.

用于热放射治疗的新型临床级超声系统的治疗交付软件。

• DOI: 10.1118/1.2064848
• 发表时间: 2005
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Novák,Petr;Moros,EduardoG;Straube,WilliamL;Myerson,RobertJ
• 通讯作者: Myerson,RobertJ

Feasibility of concurrent treatment with the scanning ultrasound reflector linear array system (SURLAS) and the helical tomotherapy system.

扫描超声反射线性阵列系统（SURLAS）和螺旋断层放射治疗系统同时治疗的可行性。

• DOI: 10.1080/02656730801929923
• 发表时间: 2008
• 期刊: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
• 作者: Peñagarícano,JoséA;Moros,Eduardo;Novák,Petr;Yan,Yulong;Corry,Peter
• 通讯作者: Corry,Peter

PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts.

• DOI: 10.1038/cgt.2008.70
• 发表时间: 2009-02
• 期刊: Cancer gene therapy
• 影响因子: 6.4

Influence of the SURLAS applicator on radiation dose distributions during simultaneous thermoradiotherapy with helical tomotherapy.

SURLAS 施源器对同步热放射治疗和螺旋断层放射治疗期间辐射剂量分布的影响。

• DOI: 10.1088/0031-9155/53/10/004
• 发表时间: 2008
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Novak,Petr;Penagaricano,JoseA;Nahirnyak,Volodymyr;Corry,Peter;Moros,EduardoG
• 通讯作者: Moros,EduardoG