Ventricular Restraint Therapy for Heart Failure

心力衰竭的心室约束治疗

• 批准号: 6999037
• 负责人: RAVI K GHANTA
• 金额: $ 5.71万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2007-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999037
• 关键词: auxiliary heart prosthesis; bioengineering /biomedical engineering; biomedical equipment development; biomedical equipment safety; cardiac myocytes; clinical biomedical equipment; disease /disorder model; echocardiography; fibrosis; heart contraction; heart failure; heart surgery; heart ventricle; hemodynamics; idiopathic dilated cardiomyopathy; intracardiac pressure; medical implant science; myocardium; oxygen consumption; pericardium; postdoctoral investigator; sheep

DESCRIPTION (provided by applicant): The major hypothesis of this proposal is that ventricular restraint therapy reduces transmural pressure, end-diastolic volume, and myocardial oxygen consumption to promote reverse remodeling in a dilated failing heart. Prior animal and initial clinical studies demonstrate the promise and feasibility of ventricular restraint therapy, however many questions remain. Our lab has developed a novel ventricular restraint device capable of quantitative ventricular restraint through the use of an epicardial balloon. Our first specific aim is to measure transmural pressure and left ventricular volume throughout the cardiac cycle, derive the pressure-volume relationship and calculate the pressure-volume area using quantitative ventricular restraint in a normal ovine heart. This aim will demonstrate the effect of ventricular restraint on ventricular mechanics and energetics in a normal heart. We will also examine the acute effect of ventricular restraint on myocardial perfusion. Our second aim is to perform these same measurements in an ovine post-infarcted model of dilated cardiomyopathy. We will perform serial measurements over a 3-month longitudinal study to evaluate end-diastolic volume, ventricle contractility, myocardial perfusion, and evidence of reverse remodeling in ventricular restraint versus control animals. Successful completion of these aims will, lead to a better understanding of the effect of ventricular restraint on ventricular physiology.

描述（由申请人提供）：该提案的主要假设是心室约束疗法降低了透壁压力，末端舒适的体积和心肌氧的消耗，以促进膨胀失败的心脏中反向重塑。先前的动物和初步临床研究证明了心室约束疗法的前景和可行性，但是仍然存在许多问题。我们的实验室开发了一种新型的心室约束装置，能够通过使用心外膜球囊来定量心室约束。我们的第一个具体目的是在整个心脏周期中测量透壁压力和左心室体积，得出压力量关系，并在正常的卵巢心脏中使用定量性心室约束来计算压力量面积。这个目标将证明心室限制对正常心脏中心室力学和能量学的影响。我们还将检查心室限制对心肌灌注的急性影响。我们的第二个目的是在卵子后的卵形后心肌病模型中进行这些相同的测量。我们将对3个月的纵向研究进行连续测量，以评估舒张末期量，心室收缩力，心肌灌注以及心室约束与对照动物的反向重塑的证据。这些目标的成功完成将使人们更好地了解心室限制对心室生理的影响。