Total Synthesis of Rameswaralide

Rameswaralide的全合成

• 批准号: 6880378
• 负责人: HIEN M NGUYEN
• 金额: $ 3.75万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2006-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6880378
• 关键词: alkenes; antiinflammatory agents; catalyst; chemical addition; chemical reaction; chemical synthesis; diterpenes; postdoctoral investigator; ruthenium

DESCRIPTION (provided by applicant): The objective of the research proposal is the design and development of a convergent and efficient strategy for the synthesis of the anti-inflammatory agent, rameswaralide. The preparation of rameswaralide and any analogues would advance their development as potential therapeutic agents for the treatment of a wide variety of inflammatory disorders such as arthritis, psoriasis, and inflammatory bowel disease. The proposed synthesis highlights both a ruthenium-catalyzed [5+2] cycloaddition and a direct catalytic enantioselective aldol reaction as key steps. The successful application of these methods in complex synthesis would provide flexible and practical route for constructing biologically important molecules that are structurally similar to rameswaralide.

描述（由申请人提供）： 该研究计划的目的是设计和开发一种聚合且有效的策略来合成抗炎药拉米斯瓦利特。拉米斯瓦利特和任何类似物的制备将促进它们作为潜在治疗剂的发展，用于治疗多种炎症性疾病，例如关节炎、牛皮癣和炎症性肠病。所提出的合成强调了钌催化的[5+2]环加成和直接催化对映选择性羟醛反应作为关键步骤。这些方法在复杂合成中的成功应用将为构建结构与拉米斯瓦利特相似的生物学重要分子提供灵活且实用的途径。