A Cavitand-Cyclodextrin Reaction Template

卡维坦-环糊精反应模板

• 批准号: 6998118
• 负责人: Sara M Butterfield
• 金额: $ 4.34万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-16 至 2006-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998118
• 关键词: chemical addition; chemical binding; chemical kinetics; chemical synthesis; cyclodextrins; intermolecular interaction; molecular assembly /self assembly; molecular shape; nuclear magnetic resonance spectroscopy; postdoctoral investigator; water

DESCRIPTION (provided by applicant): The objective of the proposed research is to investigate the ability of a covalently-linked cavitand-beta-cyclodextrin dimer to bind two chemically distinct reactive substrates and hold them in proximity to accelerate the rate of reaction between them in water. The dimer will take advantage of the unique binding properties of two well-characterized molecular receptors to template several bimolecular 1,3-dipolar cycloaddition reactions and epoxidation reactions. The proposed system is a rare example of a heterodimeric supramolecular reaction template and may inspire the evolution of designed artificial enzymes.

描述（由申请人提供）： 拟议的研究的目的是研究共价链接的cavitand-beta-cyclodextrin二聚体的能力，以结合两种化学上不同的反应性底物，并将它们保持在附近，以加速它们之间的反应速率。该二聚体将利用两个良好的分子受体的唯一结合特性来模板几个双分子1,3-二极化环载反应和环氧反应。提出的系统是异二聚体超分子反应模板的罕见例子，并可能激发设计的人工酶的演变。