Skeletal Development and Remodeling in Health, Disease and Aging

健康、疾病和衰老中的骨骼发育和重塑

• 批准号: 7001960
• 负责人: Mone Zaidi
• 金额: $ 1.3万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-16 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001960
• 关键词: aging; bone development; bone regeneration; cell biology; endocrinology; meeting /conference /symposium; molecular biology; osteocytes; osteoporosis; physiologic bone resorption; travel

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a conference titled, "Skeletal Development and Remodeling in Health, Disease and Aging" to be held from May 18 to March 21, 2005 in New York City. The conference is being organized by Mone Zaidi, MD, PhD, FRCP, Professor of Medicine and Director, Mount Sinai Bone Program, Mount Sinai School of Medicine. It is an ideal time for a conference on this subject, as the past decade has seen an enormous expansion in our understanding of how the skeleton is remodeled and repaired. Using state-of-the-art molecular technologies including Tran genesis, gene knockout, and gene array, scientists are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have helped clarify basic biological properties of the skeleton, how it responds to hormonal, cytokine and mechanical stimulation, as well as clarified path physiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. The conference will be organized along four themes: Skeletal Development and Repair, Molecular Endocrinology of Bone, Bone Cell Biology and Conservation of Skeletal Integrity, while enabling participants to engage in a highly focused discussion within each category. The final day will specifically focus on current and emerging therapies for osteoporosis. The conference will draw wide spread participation among high powered contributors in bone and cartilage biology research, as well as junior faculty member and senior postdoctoral research fellows working in the field. We also expect the meeting to be attended also by biologists, chemists, and medical doctors whose research and/or patients stand to benefit from the information exchanged at the conference. A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned.

描述（由申请人提供）：纽约科学院（NYAS）计划将于2005年5月18日至3月21日在纽约市举行一次题为“健康，疾病和衰老的骨骼发展和改造”的会议。该会议由医学博士Mone Zaidi，FRCP，医学教授兼Sinai Mount Bone计划，西奈山医学院的校长FRCP组织。 这是就此主题进行会议的理想时机，因为过去十年来，我们对骨骼如何重塑和修复的理解有了巨大的扩展。使用包括Tran Genesis，Gene敲除和基因阵列在内的最先进的分子技术，科学家们对成骨细胞的确切途径有了更好的了解，而成骨细胞却放下了新的骨骼以及骨细胞如何消除旧骨。这些研究有助于阐明骨骼的基本生物学特性，对激素，细胞因子和机械刺激的反应以及澄清的路径生理学。这种发现的最终目标是为鉴定新的细胞和分子靶标奠定牢固的科学基础，以实现未来的药物开发。 该会议将沿四个主题进行组织：骨骼发育和修复，骨骼的分子内分泌，骨细胞生物学和骨骼完整性的保守性，同时使参与者能够在每个类别中进行高度集中的讨论。最后一天将特别关注骨质疏松症的当前和新兴疗法。该会议将在骨骼和软骨生物学研究中以及在该领域工作的高级教师和高级博士后研究研究员以及高级教师和高级博士后研究员中吸引广泛的参与。我们还希望会议也将由生物学家，化学家和医生参加，他们的研究和/或患者将从会议上交换的信息中受益。还计划了一个本地论坛，该论坛将为非科学公众提供一个非正式的机会，以了解该领域的最新研究和疗法。