Ethnicity, Breast Cancer Recurrence, and Long-Term QOL

种族、乳腺癌复发和长期生活质量

• 批准号: 6928245
• 负责人: KATHY B BAUMGARTNER
• 金额: $ 28.34万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-09 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928245
• 关键词: Hispanic Americans; behavioral /social science research tag; breast neoplasms; caucasian American; clinical research; cognition; depression; fatigue; female; human mortality; human subject; lifestyle; longitudinal human study; neoplasm /cancer classification /staging; neoplasm /cancer epidemiology; neoplasm /cancer relapse /recurrence; prognosis; quality of life; questionnaires; racial /ethnic difference; telemedicine; women' s health

DESCRIPTION (provided by applicant): This application proposes a follow-up study of the New Mexico Women's Health Study (NMWHS: 1992-1996), a statewide, population-based, case-control breast cancer study, for survival, recurrence, and quality of life (QOL) approximately 14 years (y) post-diagnosis. The NMWHS included 1,556 Hispanic (H) and non-Hispanic white (NHW) women. Women newly diagnosed with in situ or invasive breast carcinoma ascertained through the New Mexico Tumor Registry (NMTR) were eligible based on the following criteria: age 30-74y, diagnosis year 1992- 1994; and New Mexico (NM) resident at diagnosis. All H cases were included, and a 33% random sample of NHW cases was identified for inclusion. The sampling fraction for NHW cases was chosen to give a similar distribution to the H cases based on age and geographic distribution of H cases ascertained during an earlier 3-y period. Of the eligible cases, participation rates were 68% (n=332) for H cases; and 77% (n=380) for NHW cases. Controls were recruited using a modified version of the Waksberg random digit-dialing method, and were frequency-matched by ethnicity, age-group, and health planning district. Of the eligible controls, participation rates were 76% (n=388) for H cases and 86% (n=456) for NHW cases. Mean age at diagnosis for cases was 54y compared to 53y for controls. In an initial review of a 10% (n=156) random sample of NMWHS participants, only 9% of 142 classified as 'alive' were not located (deceased=14). Of the 'alive' group, 82% were located within NM. Based on these results, we estimate that there will be 670 subjects to be followed for survival, 430 for recurrence (517, if deceased are included), and 969 for QOL, assuming a 75% participation rate. An additional random 12.9% sample showed 93% still in NM. Recurrence will be ascertained through self-report and verified through medical records. New primaries will be ascertained through linkage with the NMTR. Mortality will be confirmed using the National Death Index. QOL measures will be based on a standardized questionnaire used in a previous breast cancer cohort study and conducted via telephone. The proposed follow-up study will provide a unique opportunity to evaluate factors influencing survival and recurrence in long-term breast cancer survivors, and QOL compared to population-based controls. Most important, the study will allow the comparison of H vs. NHW women for these outcomes and the interaction of ethnicity with other prognostic factors in an aging cohort. There are few studies of QOL in older, long-term breast cancer survivors, and no large studies that we are aware of that have compared QOL in cases with population-based controls. There are scant data comparing H with NHW women for these outcomes. The proposed study could have important implications for treatment of H vs. NHW women and long-term care of older breast cancer survivors.

描述（由申请人提供）：本申请提议对新墨西哥州妇女健康研究（NMWHS：1992-1996）进行一项后续研究，这是一项全州范围内、以人群为基础的病例对照乳腺癌研究，旨在研究乳腺癌的生存、复发和复发情况。诊断后约 14 年 (y) 的生活质量 (QOL)。 NMWHS 包括 1,556 名西班牙裔 (H) 和非西班牙裔白人 (NHW) 女性。通过新墨西哥州肿瘤登记处 (NMTR) 确定的新诊断患有原位或浸润性乳腺癌的女性符合以下标准：年龄 30-74 岁，诊断年份 1992-1994 年；诊断时为新墨西哥州 (NM) 居民。所有 H 病例均纳入其中，并确定了 33% 的 NHW 病例随机样本纳入其中。根据前 3 年期间确定的 H 病例的年龄和地理分布，选择 NHW 病例的抽样分数，以提供与 H 病例类似的分布。在符合条件的病例中，H 病例的参与率为 68%（n=332）； NHW 病例为 77% (n=380)。使用改进版的瓦克斯伯格随机数字拨号方法招募对照组，并按种族、年龄组和健康计划区进行频率匹配。在符合资格的对照中，H 病例的参与率为 76% (n=388)，NHW 病例的参与率为 86% (n=456)。病例诊断时的平均年龄为 54 岁，而对照组的平均诊断年龄为 53 岁。在对 10% (n=156) 的 NMWHS 参与者随机样本进行初步审查时，142 名被归类为“活着”的参与者中只有 9% 未被找到（已故者=14）。在“活着”的群体中，82% 位于新墨西哥州内。根据这些结果，假设参与率为 75%，我们估计将有 670 名受试者进行生存随访，430 名受试者进行复发随访（517 名受试者，如果包括已故者），969 名受试者进行生活质量随访。额外的 12.9% 随机样本显示 93% 仍处于 NM 状态。复发将通过自我报告确定并通过医疗记录验证。新的初选将通过与 NMTR 的联系来确定。死亡率将使用国家死亡指数来确认。生活质量测量将基于之前乳腺癌队列研究中使用的标准化问卷，并通过电话进行。拟议的后续研究将提供一个独特的机会来评估影响长期乳腺癌幸存者的生存和复发的因素，以及与基于人群的对照相比的生活质量。最重要的是，该研究将能够比较 H 与 NHW 女性的这些结果以及种族与老龄化队列中其他预后因素的相互作用。关于老年长期乳腺癌幸存者生活质量的研究很少，据我们所知，也没有大型研究将病例的生活质量与基于人群的对照进行比较。对于这些结果，比较 H 与 NHW 女性的数据很少。拟议的研究可能对 H 与 NHW 女性的治疗以及老年乳腺癌幸存者的长期护理产生重要影响。