Adolescent Diet, Hormones & Breast Cancer Susceptibility

青少年饮食、激素

• 批准号: 6920557
• 负责人: JOANNE F DORGAN
• 金额: $ 110.11万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920557
• 关键词: adolescence (12-20); biomarker; body composition; bone density; breast neoplasms; cancer risk; clinical research; dietary lipid; estradiol; female; hormone regulation /control mechanism; human puberty; human subject; nutrition related neoplasm /cancer; nutrition related tag; progesterone; young adult human (21-34)

DESCRIPTION (provided by applicant): Background: Animal and ecologic studies strongly support a role of diet in breast cancer etiology, but case-control and cohort study results are equivocal. Rapid growth and maturation of the breasts occurs during adolescence, and a woman's diet as an adolescent may affect her risk of developing breast cancer more than her diet as an adult. The Dietary Intervention Study in Children (DISC) was a randomized controlled clinical trial that evaluated the effect of a reduced fat diet intervention during puberty on serum sex hormones in 301 girls who were healthy 8-10 year olds at randomization. After 5 and 7 years of participation, respectively, the intervention group had significantly 30% lower follicular phase serum estradiol and 53% lower luteal phase progesterone levels compared to the usual care group. Estradiol and progesterone are breast mitogens that regulate breast development during puberty and these differences could potentially influence participants' risk of developing breast cancer as adults. We propose to take advantage of this unique opportunity to evaluate the effect of a diet intervention during adolescence on biomarkers associated with breast cancer risk to improve our understanding of breast development and the origins of breast cancer. Specific Aims: Our primary aim is to determine the long-term effect of the DISC intervention on serum progesterone levels in early adulthood. Secondary aims are to determine the effects of the DISC intervention on serum estradiol levels, bone mineral density, and breast density in early adulthood. Design: A follow-up visit will be conducted with the 301 girls who participated in DISC and who are now in their twenties. Data will be collected on demographics, medical history, menstrual and reproductive history, physical activity, and diet. Heights and weights, serum progesterone and estradiol levels, bone mineral density, and breast density will be measured. Significance: The proposed study will determine, as part of a controlled clinical trial, the effects of diet during adolescence on breast cancer risk via effects on serum hormones, breast density, and bone mineral density. These biomarkers are three of the strongest risk factors for breast cancer and could readily be affected by adolescent diet. Because diet is a modifiable risk factor, results of this proposed study could be used to develop strategies for prevention.

描述（由申请人提供）：背景：动物和生态学研究强烈支持饮食在乳腺癌病因中的作用，但是病例控制和队列研究结果是模棱两可的。乳房的快速生长和乳房的成熟发生在青春期，而女性饮食作为青少年可能会影响她患乳腺癌的风险，而不是成年人的饮食。对儿童的饮食干预研究（DISC）是一项随机对照临床试验，该试验评估了青春期期间脂肪饮食干预降低对301名健康8-10岁儿童在随机身份健康的女孩的影响。在参与5年和7年之后，与通常的护理组相比，干预组的卵泡期血清雌二醇降低了30％，黄质孕酮的孕酮水平降低了53％。雌二醇和孕酮是乳腺促促促促乳腺菌素，可调节青春期乳房的发育，这些差异可能会影响参与者成年乳腺癌的风险。我们建议利用这一独特的机会来评估青春期饮食干预对与乳腺癌风险相关的生物标志物的影响，以提高我们对乳腺癌的理解和乳腺癌的起源。具体目的：我们的主要目的是确定椎间盘干预对成年初期血清孕激素水平的长期影响。次要目的是确定椎间盘干预对成年早期血清雌二醇水平，骨矿物质密度和乳房密度的影响。设计：将与参加碟片且二十多岁的301名女孩进行后续访问。数据将收集有关人口统计学，病史，月经和生殖史，体育锻炼和饮食的数据。将测量高度和体重，血清孕酮和雌二醇水平，骨矿物质密度和乳房密度。意义：拟议的研究将确定作为对照临床试验的一部分，青春期饮食对乳腺癌风险的影响通过对血清激素，乳房密度和骨骼矿物质密度的影响。这些生物标志物是乳腺癌最强的危险因素的三个，很容易受到青少年饮食的影响。由于饮食是一种可修改的危险因素，因此该拟议研究的结果可用于制定预防策略。