Neurochemical and Behavioral Correlates of ETOH Effects

乙醇效应的神经化学和行为相关性

• 批准号: 6917129
• 负责人: RUEBEN A. GONZALES
• 金额: $ 24.95万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6917129
• 关键词: Neurochemical; Behavioral; Correlates; ETOH; Effects

DESCRIPTION (provided by applicant): This is a proposal for the continuation of a training grant to support six predoctoral and three postdoctoral fellows who will be broadly and intensively trained to conduct research on alcoholism. Training areas span the breadth of state-of-the-art approaches including molecular biology and genetics, electrophysiology, cellular imaging, neurochemistry, and behavior. Research models include both animal and human. The training program will promote and support collaborative research. Molecular biology training will encompass studies of the function of ligand-gated ion channels in cellular expression systems (Mihic, Harris), development of new transgenic animal models (Harris, Mihic), and identification of ethanol responsive genes (Iyer, Bergeson, Harris, Mihic). Genetics training will involve genotyping of human and animal subjects (Fromme, Harris, Bergeson, lyer). Electrophysiological and microscopic imaging training will comprise experiments with whole cell and intracellular methods in single cells and in brain slices (Morrisett, Mihic, Harris). Training in neurochemistry will focus on intracellular and extracellular signaling mechanisms with an emphasis on phosphorylation (Morrisett, Leslie), release and transport of glutamate, dopamine, and other neurotransmitters (Gonzales, Harris), and expression of synaptic proteins (Leslie, Morrisett). Research training in the behavioral effects of ethanol (motor skills, reinforcement, anxiety, and withdrawal) will be done (,Duvauchelle, Harris, Gonzales, Bergeson). Training in psychosocial aspects of alcohol research (Fromme) and the interaction of genotype and alcohol drinking in humans (Fromme, Bergeson, Harris, lyer) will also be done. The training program will continue to emphasize professional development (improvement of oral and written communication skills) (Erickson). Postdoctoral fellows will choose a project at the onset of their training. Predoctoral trainees will rotate through the laboratories of selected faculty members prior to choosing an advisor for dissertation research. Predoctoral students will be required to complete a series of core course requirements covering ethanol's actions on the central nervous system, scientific ethics, experimental design, and statistical analysis. We will continue to focus on minority recruitment. The training program has an excellent record and will continue to focus on producing well qualified alcohol researchers.

描述（由申请人提供）： 这是一项关于继续提供培训补助金以支持六名 博士前研究员和三名博士后研究员将进行广泛而深入的研究 受过培训以进行酗酒研究。培训领域涵盖广泛 最先进的方法，包括分子生物学和遗传学， 电生理学、细胞成像、神经化学和行为。研究 模型包括动物和人类。该培训计划将促进和 支持合作研究。分子生物学培训将包括 配体门控离子通道在细胞表达中的功能研究 系统（Mihic，Harris），开发新的转基因动物模型（Harris， Mihic），以及乙醇反应基因的鉴定（Iyer、Bergeson、 哈里斯、米希奇）。遗传学培训将涉及人类和动物的基因分型 主题（Fromme、Harris、Bergeson、lyer）。电生理学和 显微成像训练将包括全细胞实验和 单细胞和脑切片的细胞内方法（Morrisett、Mihic、 哈里斯）。神经化学培训将重点关注细胞内和 以磷酸化为重点的细胞外信号传导机制 （莫里塞特，莱斯利），谷氨酸、多巴胺和其他物质的释放和运输 神经递质（冈萨雷斯、哈里斯）和突触蛋白的表达 （莱斯利，莫里塞特）。乙醇行为影响的研究培训 （运动技能、强化、焦虑和退缩）将会完成 （杜沃切尔、哈里斯、冈萨雷斯、伯杰森）。心理社会方面的培训 酒精研究 (Fromme) 以及基因型和酒精的相互作用 人类（Fromme、Bergeson、Harris、lyer）饮酒也将完成。这 培训计划将继续强调专业发展 （提高口头和书面沟通技巧）（埃里克森）。 博士后研究员将在培训开始时选择一个项目。 博士前培训生将在选定教师的实验室轮换 在选择论文研究顾问之前的成员。博士前 学生将被要求完成一系列核心课程要求 涵盖乙醇对中枢神经系统的作用、科学伦理、 实验设计和统计分析。我们将继续关注 少数民族招募。该培训计划有着良好的记录，并将 继续专注于培养高素质的酒精研究人员。