Improved Susceptometry to Measure Body Iron Stores

改进的电感受计测量体内铁储备

• 批准号: 6913994
• 负责人: SANKARAN KUMAR
• 金额: $ 26.14万
• 依托单位: QUANTUM MAGNETICS, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6913994
• 关键词: bioengineering /biomedical engineering; biomagnetism measurement; biomedical equipment development; clinical research; cost effectiveness; diagnosis design /evaluation; diagnosis quality /standard; ferritin; hereditary hemochromatosis; human subject; iron; iron metabolism; iron poisoning; liver; molecular /cellular imaging; noninvasive diagnosis; obesity; thalassemia

DESCRIPTION (provided by applicant): This R21 program will fundamentally improve the precision and reduce the cost of magnetic susceptometry for noninvasive measurements of body iron stores. Where existing susceptometers use expensive SQUID sensors that require liquid helium, the new susceptometer will use inexpensive magnetic sensors working at room temperature. In preliminary studies, a first-generation susceptometer with room-temperature sensors showed a good correlation (r=0.98) with an existing SQUID system. The next-generation susceptometer will resolve lower iron levels, in fatter patients, than any existing susceptometer. As a model system, this program focuses on liver iron measurements, which are the best indicator of total body iron. Innovative susceptometer coil geometry will minimize errors due to the susceptibility responses of the lung and abdominal wall. Additional errors in current measurement systems will be further reduced, after correcting for lung and abdominal-wall susceptibilities, as well as by improving the water bag that compensates for the diamagnetic background response of the body. These improved susceptometry techniques may ultimately be used to measure iron in the brain, heart and other organs, and to detect tissue-specific magnetic tracers that highlight certain molecules and cell types, signal the presence of cancers, or indicate the function of the lymph nodes, liver and spleen.

描述（由申请人提供）： 该R21程序将从根本上提高精度并降低磁性苏门克储存的无创测量成本。如果现有的帝国计使用需要液态氦气的昂贵鱿鱼传感器，则新的启示仪将使用在室温下工作的廉价磁性传感器。在初步研究中，带有室温传感器的第一代启示仪与现有的鱿鱼系统具有良好的相关性（r = 0.98）。与任何现有的模拟仪相比，下一代的模拟计将使胖患者的铁水平较低。作为模型系统，该程序专注于肝铁测量，这是全身铁的最佳指标。创新的启示仪线圈几何形状将由于肺部和腹壁的敏感性响应而最大程度地减少错误。在纠正肺和腹壁的敏感性后，以及通过改善补偿人体二氧化背景反应的水袋后，将进一步降低当前测量系统中的其他错误。 这些改进的苏联技术最终可用于测量大脑，心脏和其他器官中的铁，并检测突出某些分子和细胞类型的组织特异性磁迹弹器，表明癌症的存在，或指示淋巴结，肝脏和脾脏的功能。