Pre-Chemotherapeutic Care of HCV Infected Drug Users

HCV 感染吸毒者的化疗前护理

• 批准号: 6945393
• 负责人: DAWN A FISHBEIN
• 金额: $ 17.42万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6945393
• 关键词: AIDS therapy; HIV infections; adult human (21+); alcoholism /alcohol abuse; behavioral /social science research tag; chronic disease /disorder; clinical research; comorbidity; depression; drug abuse therapy; epidemiology; experience; health behavior; health care service utilization; health services research tag; hepatitis A; hepatitis B; hepatitis C; high risk behavior /lifestyle; human subject; microorganism disease chemotherapy; patient care; patient oriented research; sex behavior; substance abuse related behavior; substance abuse related disorder; therapy compliance

DESCRIPTION (provided by applicant): The care of chronic hepatitis C (HCV) infection among drug users, many of whom are co-infected with HIV, is an important public health problem. For drug users with chronic HCV infection, alcohol and active drug abuse, high rates of depression, susceptibility to hepatitis A and B infections, and HIV co-infection are only a few of the variables that affect engagement in and outcome of HCV chemotherapy. Attention to these "pre-chemotherapeutic" factors prepares drug users for future and possibly more efficacious HCV chemotherapy. However, little is known about whether these "pre-chemotherapeutic" factors are successfully addressed in the context of chronic HCV management. The candidate proposes the following specific aims: 1) To determine rates of engagement in pre-chemotherapeutic care among drug users with chronic HCV infection. 2) To determine factors associated with awareness and acceptance of interventions other than specific chemotherapy for reducing the progression of chronic HCV infection and preparing for future chemotherapy. The candidate proposes a five-year prospective study of engagement in and factors associated with pre-chemotherapeutic care for hepatitis C infection, among HCV-infected drug users participating in two ongoing cohort studies of men and women with or at risk for HIV. Participants will be screened and enrolled at a semi-annual research visit for the parent studies. At each semi-annual research visit, study participants will undergo standardized interviews to gather data on demographics, sexual and drug-using behaviors and medical history, including symptoms of and treatment for hepatitis. In addition, blood will be drawn for laboratory assays including HCV antibody and HCV RNA levels. The purpose of this K23 grant proposal is to support this candidate as she develops her clinical research career and undertakes studies in HCV-infected drug users with or at risk for HIV, under the mentorship of experienced investigators.

描述（由申请人提供）： 吸毒者中慢性丙型肝炎（HCV）感染的护理，其中许多人与艾滋病毒共同感染了，这是一个重要的公共卫生问题。对于患有慢性HCV感染，酒精和活跃药物滥用的药物使用者，抑郁症的高率，对乙型肝炎和B感染的易感性以及HIV共感染只是影响HCV化学疗法参与和结果的少数变量。注意这些“化学前治疗性”因素为吸毒者准备了未来，并可能更有效的HCV化学疗法。但是，对于在慢性HCV管理的背景下是否成功解决了这些“化学前治疗性”因素，知之甚少。 候选人提出以下具体目标： 1）确定患有慢性HCV感染的药物使用者在化学治疗前的参与率。 2）确定与认识和接受干预措施相关的因素，而不是特定的化学疗法以减少慢性HCV感染的进展并为将来的化疗做准备。 该候选人提出了一项为期五年的前瞻性研究，研究与乙型肝炎感染前的化学治疗护理相关的因素，其中HCV感染的吸毒者参与了两项正在进行的对患有艾滋病毒或患有艾滋病毒风险的男性和女性的持续研究。参与者将被筛选并参与父母研究的半年度研究访问。在每次半年度研究访问中，研究参与者将接受标准化的访谈，以收集有关人口统计学，性和吸毒行为和病史的数据，包括肝炎的症状和治疗症状。此外，将吸收血液进行实验室测定，包括HCV抗体和HCV RNA水平。 在经验丰富的调查人员的指导下，这项K23赠款提案的目的是在发展自己的临床研究生涯并在患有HCV感染的药物使用者或面临艾滋病毒风险的HCV吸毒者方面进行研究，以支持该候选人。