Training Grant in Dynamic Aspects of Chemical Biology

化学生物学动态方面的培训补助金

• 批准号: 6845044
• 负责人: KRISTIN Susan BOWMAN-JAMES
• 金额: $ 21.75万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6845044
• 关键词: Training; Grant; Dynamic; Aspects; Chemical

DESCRIPTION (provided by applicant): This application requests continued support for the doctoral training program in Dynamic Aspects of Chemical Biology in the Departments of Chemistry, Medicinal Chemistry, and Molecular Biosciences at the University of Kansas. This training program aims to educate doctoral graduates in the chemical sciences who will have a working level of biological information and skills, and doctoral graduates in the biological sciences who will have a command of chemical information and skills. The program at the University of Kansas takes advantage of a local tradition of over 50 years of close and effective collaboration among scientists at the interface of chemistry, biology, and the pharmaceutical sciences. Mentors will be drawn from the participating departments: 11.5 faculty members from Chemistry, 6.5 from Molecular Biosciences, 6 from Medicinal Chemistry, and 1 from Pharmacology and Toxicology (the 0.5 reflects a faculty member with joint appointments in Medicinal Chemistry and Chemistry). Support is requested for seven trainees, an increase of one from the previous submission. Trainees complete a program that features focused doctoral education and research in an area of established strength; a curriculum of courses that broadens the information and skills of trainees into areas beyond departmental boundaries; research rotations that give trainees personal research experience in all areas of the program; and participation in both organization of and presentation at special seminars and an annual symposium. The doctoral research projects of trainees fall into one of three areas: (1) synthesis of molecules of biological relevance; (2) biophysical structure analysis; (3) enzyme mechanisms and biomolecular dynamics. The training-grant curriculum begins with core courses in bioinformatics and/or molecular modeling, along with a course, Issues in Scientific Integrity. Then each chemistry and medicinal chemistry student is required to take at least one elective course in molecular biosciences and vice versa. In addition, trainees meet all doctoral requirements of their home departments. All trainees carry out two research rotations. Trainees manage and participate in the Annual Training Grant Symposium as well as in inviting speakers for a Chemical Biology seminar.

描述（由申请人提供）：本申请请求继续支持堪萨斯大学化学系、药物化学系和分子生物科学系化学生物学动态方面的博士培训项目。 本培养项目旨在培养具有工作水平的生物信息和技能的化学科学博士毕业生和具有化学信息和技能的生物科学博士毕业生。堪萨斯大学的该项目利用了当地化学、生物学和制药科学领域科学家之间 50 多年密切有效合作的传统。导师将从参与院系中抽取：化学系11.5名，分子生物科学系6.5名，药物化学6名，药理学和毒理学1名（0.5名是药物化学和化学联合聘任的教师）。请求为七名受训人员提供支持，比上次提交的内容增加了一名。学员完成一个项目，该项目的重点是在既定优势领域进行博士教育和研究；一系列课程，将受训者的信息和技能扩展到部门界限之外的领域；研究轮换为学员提供项目所有领域的个人研究经验；参与特别研讨会和年度研讨会的组织和演讲。学员的博士研究项目属于三个领域之一：（1）生物相关分子的合成； (2)生物物理结构分析； (3)酶机制和生物分子动力学。培训资助课程从生物信息学和/或分子建模核心课程开始，以及科学完整性问题课程。然后，每个化学和药物化学学生都必须至少选修一门分子生物科学课程，反之亦然。此外，学员满足其所在院系的所有博士要求。所有学员都进行两次研究轮换。学员管理并参加年度培训补助金研讨会，并邀请演讲者参加化学生物学研讨会。