Antifolates Against Mycobacterial Infections in AIDS

抗叶酸剂对抗艾滋病分枝杆菌感染

• 批准号: 6631969
• 负责人: William W Barrow
• 金额: $ 42.54万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6631969
• 关键词: AIDS; Actinomycetales infection; Mycobacterium avium; Mycobacterium tuberculosis; Vero cells; antitubercular agents; bacterial proteins; chemical synthesis; dihydrofolate reductase; drug screening /evaluation; enzyme activity; folate antagonist; laboratory mouse; microorganism disease chemotherapy; molecular cloning; nonhuman therapy evaluation; oxidoreductase inhibitor; recombinant proteins; respiratory disorder chemotherapy

项目成果

Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.

新型含硼非经典抗叶酸剂：合成和初步生物学和结构评估。

• 发表时间: 2007-07-12
• 影响因子: 7.3
• 作者: Reynolds, Robert C;Campbell, Shiela R;Fairchild, Ralph G;Kisliuk, Roy L;Micca, Peggy L;Queener, Sherry F;Riordan, James M;Sedwick, W David;Waud, William R;Leung, Adelaine K W;Dixon, Richard W;Suling, William J;Borhani, David W
• 通讯作者: Borhani, David W

New antifolate inhibitors for Mycobacterium avium.

鸟分枝杆菌的新型抗叶酸抑制剂。

• 发表时间: 2006-09
• 作者: Barrow, E W;Suling, W J;Seitz, L E;Reynolds, R C;Barrow, W W
• 通讯作者: Barrow, W W

New Mycobacterium avium antifolate shows synergistic effect when used in combination with dihydropteroate synthase inhibitors.

新型鸟分枝杆菌抗叶酸剂与二氢蝶酸合酶抑制剂联合使用时显示出协同效应。

• 发表时间: 2005-11
• 作者: Suling, W J;Seitz, L E;Reynolds, R C;Barrow, W W
• 通讯作者: Barrow, W W

Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase.

鸟分枝杆菌二氢叶酸还原酶的底物和抑制剂特异性。

• 发表时间: 2007-07
• 作者: Bock, Ronnie A;Soulages, Jose L;Barrow, William W
• 通讯作者: Barrow, William W