Identifying EP/MEG sources in strabismus and amblyopia

识别斜视和弱视的 EP/MEG 来源

基本信息

批准号：
6929122
负责人：
STANLEY A KLEIN
金额：
$ 19万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-08-01 至 2008-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6929122
关键词：
amblyopia bioimaging /biomedical imaging brain mapping clinical research electroencephalography evoked potentials eye coordination disorder functional magnetic resonance imaging human subject magnetoencephalography method development psychophysics visual cortex

项目摘要

DESCRIPTION (provided by applicant): The over-arching goal of this proposal is to develop powerful new methods for identifying multiple cortical sources associated with different early visual areas to reveal the cortical loci of abnormality in amblyopia and strabismic suppression. Technologies such as fMRI, EEG and MEG have enabled us to image the human brain during cognition, but have had limited application for the study of cortical dynamics of closely spaced visual areas. Modem fMRI methods can be used to identify some participating cortical loci but can easily overlook others since a disruption of temporal information within an area may not cause an overall change in cortical activation. Moreover, fMRI's limited temporal resolution obscures feedback processes between cortical areas. EEG and MEG have fine temporal resolution but to date have had limited success in identifying individual cortical sources. The project goals are to develop new methods that solve these problems and apply them to understanding the cortical deficit associated with amblyopia and strabismic suppression. Three Specific Aims are proposed: Aim 1: To develop new VEP/MEG methods for separating multiple cortical sources located in striate and extrastriate areas. Classical methods alone are unable to separate closely spaced early and late visual areas. A successful outcome of this aim will enable cortical dynamics of both early and late visual areas to be reliably distinguished. Aim 2: Amblyopia is a developmental disorder of spatial vision, which occurs in about 3% of the population. Many years of research confirm the deficit is cortical in origin with recent findings indicating involvement of visual areas beyond V1. To reveal the spatio-temporal participation of different cortical areas that contribute to amblyopia and strabismic suppression, we will apply the new evoked response (ER) methodology of Aim 1 that solves past limitations in identifying multiple cortical sources. The research will be able to determine not only where amblyopic/strabismic loss has occurred, but also the role of feedback between visual areas. Aim 3: Use fMRI and psychophysics to validate and extend the findings of ER experiments on the cortical site(s) of the deficit in amblyopia. In addition, novel stimuli such as ambiguous figures that are not readily employed using ER methods, will be employed to examine and distinguish areas that participate in the deficit associated with amblyopia.

描述（由申请人提供）：该提案的总体目标是开发强大的新方法，以识别与不同早期视觉区域相关的多个皮质来源，以揭示弱视和斜率抑制的异常皮质基因座。诸如fMRI，EEG和MEG之类的技术使我们能够在认知过程中对人的大脑进行成像，但在研究紧密间隔区域的皮质动力学方面的应用有限。调制解调器fMRI方法可用于识别一些参与的皮质基因座，但可以轻松忽略其他地方，因为区域内的时间信息中断可能不会导致皮质激活的总体变化。此外，fMRI的有限时间分辨率掩盖了皮质区域之间的反馈过程。脑电图和梅格具有良好的时间分辨率，但迄今为止在识别单个皮质来源方面取得了有限的成功。项目目标是开发解决这些问题的新方法，并将它们应用于了解与弱视和斜视抑制相关的皮质缺陷。提出了三个具体目标：目标1：开发新的VEP/MEG方法，以分离位于条纹和腹部外区域的多个皮质来源。仅经典方法就无法分离紧密间隔的早期和晚期视觉区域。这个目标的成功结果将使早期和晚期视觉区域的皮质动态可靠地区分。 AIM 2：弱视是一种空间视力的发育障碍，发生在大约3％的人群中。多年的研究证实了赤字的起源是皮质的，最近的发现表明V1以外的视觉区域参与。为了揭示有助于弱视和斜率抑制的不同皮质区域的时空参与，我们将应用AIM 1的新诱发响应（ER）方法，该方法解决了过去的限制，以识别多个皮质来源。这项研究将不仅能够确定弱视/斜视损失发生的地方，还可以确定视觉区域之间反馈的作用。 AIM 3：使用fMRI和心理物理学来验证和扩展弱视赤字的皮质部位上ER实验的发现。此外，将采用新的刺激，例如不容易使用ER方法使用的模棱两可的数字来检查和区分参与与弱视相关的赤字的区域。