Expiratory muscle training in patients with Parkinson's

帕金森病患者的呼气肌训练

• 批准号: 6867528
• 负责人: CHRISTINE M SAPIENZA
• 金额: $ 25.46万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6867528
• 关键词: Parkinson' s disease; clinical research; data collection methodology /evaluation; human subject; human therapy evaluation; interview; mechanical pressure; muscle function; muscle strength; neuromuscular system; outcomes research; patient oriented research; pulmonary respiration; questionnaires; respiratory airflow measurement; respiratory airway volume; respiratory muscles; respiratory reflex; speech; statistics /biometry; swallowing; therapy design /development; training

This project tests the outcome of a novel training method for strengthening the muscles of the respiratory system. Targeting the expiratory muscles, the technique is referred to as expiratory muscle strength training (EMST). EMST provides the user with an experimental high-pressure threshold device which places a high physiological load on the muscles during breathing. The treatment lasts 4 weeks and the majority of the training takes place in the person's home. We intend to test the outcome of EMST in a group of individuals with idiopathic Parkinson disease (IPD). Parkinson's disease is a debilitating disease with well-recognized adverse effects on motor function including breathing, cough, swallow and speech. The general purpose of this research is to first determine if those with a specific severity of IPD can improve expiratory muscle strength and secondly to determine what outcome variables are affected by the improvements in expiratory muscle strength. We anticipate improvements in breathing, cough, swallow and speech following treatment that are attributable to the training technique. Study of three groups of 30 subjects with Hoehn & Yahr, stage I-III IPD in a treatment, sham and control group will define the therapeutic effect of this technique. Quantitative measures include measures of volume, flow, sound pressure level and videoflourographic indices as well as listener perception tests to determine the technique's impact on overall sound quality and speech intelligibility. Results from this project will provide new information about the EMST program as a novel technique. The goals of the grant meet the mission of the R21. Its potential impact is high due to the therapy program's innovative nature and potential cost-effectiveness as a treatment approach.

该项目测试了一种增强呼吸系统肌肉的新型训练方法的效果。该技术以呼气肌为目标，被称为呼气肌力量训练（EMST）。 EMST 为用户提供了一种实验性高压阈值装置，该装置在呼吸过程中对肌肉施加较高的生理负荷。治疗持续 4 周，大部分训练在患者家中进行。我们打算在一组特发性帕金森病 (IPD) 患者中测试 EMST 的结果。帕金森病是一种使人衰弱的疾病，众所周知会对呼吸、咳嗽、吞咽和言语等运动功能产生不利影响。本研究的总体目的是首先确定具有特定严重程度的 IPD 的患者是否可以改善呼气肌力量，其次确定哪些结果变量会受到呼气肌力量改善的影响。我们预计治疗后呼吸、咳嗽、吞咽和言语方面的改善可归因于训练技术。对 Hoehn & Yahr I-III 期 IPD 治疗组、假手术组和对照组三组 30 名受试者进行的研究将确定该技术的治疗效果。定量测量包括音量、流量、声压级和视频荧光指数的测量以及听众感知测试，以确定该技术对整体音质和语音清晰度的影响。该项目的结果将提供有关 EMST 计划作为一项新技术的新信息。该赠款的目标符合 R21 的使命。由于该治疗方案的创新性和作为治疗方法的潜在成本效益，其潜在影响很大。