Mentored Patient-Oriented Research Career Development Aw

指导以患者为中心的研究职业发展Aw

• 批准号: 6887369
• 负责人: KATHRYN M RYDER
• 金额: $ 14.65万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887369
• 关键词: 1,25 dihydroxycholecalciferol; biomarker; blood chemistry; bone density; bone metabolism; calcium metabolism; clinical trials; diet therapy; dietary supplements; disease /disorder prevention /control; gastrointestinal nutrient absorption; human middle age (35-64); human old age (65+); human subject; human therapy evaluation; longitudinal human study; magnesium; magnesium deficiency; nutrition related tag; osteoporosis; outcomes research; parathyroid hormones; pathologic bone resorption; patient oriented research; placebos

PROPOSAL (Adapted from the applicant's abstract): The candidate is Assistant Professor of Medicine at the UTSM, Memphis. UTSM has a Clinical Research Center that provides resources through which the candidate can perform patient-oriented clinical research. The Departments of Internal and Preventive Medicine have numerous ongoing experimental and observational trials. This provides opportunities for the candidate to collaborate with faculty. The candidate has proposed a five-year training plan, with the long- term goal of practicing medicine, performing patient-oriented research and teaching residents and students. The candidate also plans to serve as a resource and mentor for faculty who wish to learn research design and literature interpretation. The candidate will complete a Master's degree in epidemiology and take advanced courses beyond the degree. She will attend research meetings in the Metabolic Bone Center, the Department of Preventive Medicine, and the St. Jude-LeBonheur-UTSM Bone Coalition. Finally, the candidate will investigate the effect of magnesium (Mg) on bone loss in healthy older adults. Mg supplementation has attractive but unproven benefits in bone health. In uncontrolled and unblinded trials, Mg supplementation leads to large gains in bone density. The mechanism of action is not known. Severe Mg deficiency has an impact on calciotropic hormones, and changes in these hormones may have a direct effect on bone as well as an effect on gut calcium absorption. Whether Mg supplementation affects calciotropic hormones in healthy subjects without severe Mg deficiency is not known. Mild Mg deficiency may be common, since as many as 75% of the elderly do not meet the estimated average requirement for Mg. This study will test the following hypotheses: 1) Mg supplementation reduces bone resorption in healthy adults; 2) Mg supplementation increases gut calcium absorption; and 3) The increase in calcium absorption occurs through changes in circulating levels of calciotropic hormones. This will be a double-blinded placebo-controlled trial of Mg (500 mg/day) in 92 healthy men and women between the ages of 55-75.

提案（根据申请人的摘要改编）：候选人是助理 孟菲斯UTSM医学教授。 UTSM有临床研究 提供候选人可以执行的资源的中心 面向患者的临床研究。 内部和 预防医学有许多正在进行的实验和观察性 试验。 这为候选人提供了与之合作的机会 学院。 候选人提出了五年的培训计划，长期 练习医学，进行以患者为导向的研究和 教居民和学生。 候选人还计划担任 希望学习研究设计的教师的资源和导师 文学解释。 候选人将完成硕士学位 流行病学并参加高级课程。 她会参加 预防局代谢骨中心的研究会议 医学和圣裘德 - lebonheur-UTSM骨联盟。 最后， 候选人将研究镁（MG）对骨质流失的影响 健康的老年人。 补充毫克具有吸引力但未经证实的好处 在骨骼健康中。 在不受控制的无盲试验中，补充毫克 导致骨密度大幅增长。 作用机理尚不清楚。 严重的毫克缺乏对钙的激素有影响，并且变化 这些激素可能对骨骼有直接影响以及对肠道的影响 钙吸收。 补充毫克是否会影响钙的激素 在没有严重MG缺乏的健康受试者中，尚不清楚。 轻度毫克 缺乏可能很常见，因为多达75％的老年人不符合 估计的平均需求。 这项研究将测试以下 假设：1）补充毫克可减少健康成年人的骨吸收； 2）补充毫克会增加肠道钙的吸收； 3）增加 钙吸收是通过循环水平的变化而发生的 钙称激素激素。 这将是双盲安慰剂对照试验 在55-75岁之间的92位健康男性和女性中，毫克（500 mg/day）的含量。

项目成果

Does a history of non-vertebral fracture identify women without osteoporosis for treatment?

有非椎骨骨折史是否可以确定没有骨质疏松症的女性接受治疗？

• DOI: 10.1007/s11606-008-0622-0
• 发表时间: 2008
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Ryder,KathrynM;Cummings,StevenR;Palermo,Lisa;Satterfield,Suzanne;Bauer,DouglasC;Feldstein,AdrianneC;Schousboe,JohnT;Schwartz,AnnV;Ensrud,Kristine;FractureInterventionTrialResearchGroup
• 通讯作者: FractureInterventionTrialResearchGroup

A captive audience: a pilot study of screening and counseling hospitalized women for fracture risk.

俘虏观众：一项针对住院妇女骨折风险筛查和咨询的试点研究。

• DOI: 10.1007/s11606-007-0137-0
• 发表时间: 2007
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Ryder,KathrynM;Kessler,LoriA;Jones,CarolB;Shorr,RonaldI
• 通讯作者: Shorr,RonaldI

Teriparatide is safe and effectively increases bone biomarkers in institutionalized individuals with osteoporosis.

特立帕肽安全且有效地增加住院骨质疏松症患者的骨生物标志物。

• DOI: 10.1007/s00774-009-0123-1
• 发表时间: 2010
• 期刊: Journal of bone and mineral metabolism
• 影响因子: 3.3
• 作者: Ryder,KathrynM;Tanner,SBobo;Carbone,Laura;Williams,JohnE;Taylor,HenryM;Bush,Andrew;Pintea,Victorina;Watsky,MitchellA
• 通讯作者: Watsky,MitchellA

Poor health, but not fracture and fall risk, is associated with nonattendance at bone mineral density screening.

不参加骨矿物质密度筛查与健康状况不佳有关，但与骨折和跌倒风险无关。

• DOI: 10.1097/smj.0b013e318258ffca
• 发表时间: 2012
• 期刊: Southern medical journal
• 影响因子: 1.1
• 作者: Ryder,KathrynM;Bush,Andrew;Womack,Catherine;Pitts,Wayne
• 通讯作者: Pitts,Wayne