Gender and Hormonal Differences in Parkinson's Disease

帕金森病的性别和荷尔蒙差异

• 批准号: 6891913
• 负责人: Rachel Saunders-Pullman
• 金额: $ 17.39万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891913
• 关键词: Parkinson' s disease; abnormal involuntary movement; clinical research; disease /disorder etiology; disease /disorder proneness /risk; epidemiology; estrogen receptors; estrogens; gender difference; hormone regulation /control mechanism; human subject; longitudinal human study; neuropathology; neuropharmacology; neuropsychological tests; pathologic process; pharmacokinetics; phlebotomy; sex hormones; statistics /biometry; testosterone

DESCRIPTION (provided by applicant): This application is directed to the career development of Dr. Rachel Saunders-Pullman as a clinical researcher in the study of hormonal effects on Parkinson's Disease and other neurodegenerative disorders. During the period of this grant she will focus on gender differences and the role of hormones in the development of Parkinson's disease (PD). As hormone physiology is complex, and estrogenic compounds can be carcinogenic as well as beneficial, the assessment of the role of estrogen and gender differences and the planning of clinical trials requires multi-disciplinary knowledge and training. The candidate has constructed a training program with areas of emphasis in epidemiology, neuroscience and neuroendocrinology, cognition and movement disorders using an integrated plan of research, coursework, lectures, and rounds. Her primary sponsor, Dr. Richard Lipton will oversee the methods and the candidate's development in epidemiology and cognition as well as the overall training. The co-sponsor, Dr. Susan Bressman will provide guidance in the field of movement disorders. A consultant team of Dr. Anne Etgen, Dr. Nanette Santoro and Dr. Charles Hall will complement with expertise in neuroscience and neuroendocrinology and biostatistics, respectively. In order to address gender related differences in risk of PD and clinical features of PD, and whether hormonal factors account for these differences, three separate studies with differing study designs are proposed. These studies were designed to provide complementary answers to specific research questions and to give the candidate hands-on, mentored exposure to three major types of epidemiologic research 1) a clinic-based prospective study of gender differences in the natural history and disease course in early PD, 2) a case-control study of pharmacy records to assess whether exogenous estrogen decreases the risk of PD and 3) a cross-sectional and a prospective evaluation of the role of gender and endogenous hormone levels on motor control measures in aging and pre-clinical parkinsonism in an established cohort study. Through the aggregate of the training program and supervised research, the candidate will emerge as an independent researcher well prepared to answer questions of the role of hormones in neurodegenerative diseases and movement disorders.

描述（由申请人提供）：此申请针对Rachel Saunders-Pullman博士作为临床研究人员的职业发展，以研究荷尔蒙对帕金森氏病和其他神经退行性疾病的影响。在这笔赠款期间，她将专注于性别差异以及激素在帕金森氏病（PD）发展中的作用。由于激素生理学很复杂，雌激素化合物可以是致癌性和有益的，因此评估雌激素和性别差异的作用，临床试验的计划需要多学科知识和培训。该候选人通过研究，课程工作，讲座和巡回赛的综合计划，建立了一个培训计划，该计划在流行病学，神经科学和神经内分泌学，认知和运动障碍方面具有重点。她的主要赞助商理查德·利普顿（Richard Lipton）博士将监督这种方法和候选人在流行病学和认知方面的发展以及整体培训。共同发起人苏珊·布雷斯曼（Susan Bressman）博士将在运动障碍领域提供指导。 Anne Etgen博士，Nanette Santoro博士和Charles Hall博士的顾问团队将分别在神经科学和神经内分泌学和生物统计学方面提供专业知识。 为了解决PD风险和PD临床特征的性别相关差异，以及激素因素是否解释了这些差异，提出了三项针对不同研究设计的单独研究。这些研究旨在为特定研究问题提供补充答案，并为候选人动手实践，对三种主要类型的流行病学研究暴露。在一项既定的队列研究中，内源性激素水平在衰老和临床前帕金森氏症中的运动控制测量中。通过培训计划和监督研究的汇总，候选人将成为一名独立的研究人员，准备回答有关激素在神经退行性疾病和运动障碍中的作用的问题。