HIV Outcomes Research and Training in Uganda

乌干达的艾滋病毒结果研究和培训

• 批准号: 6952288
• 负责人: DAVID Roy BANGSBERG
• 金额: $ 13.57万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952288
• 关键词: AIDS; AIDS therapy; Africa; HIV infections; alcoholism /alcohol abuse; antiAIDS agent; antiviral agents; behavioral /social science research tag; clinical research; data collection methodology /evaluation; disease /therapy duration; drug interactions; drug resistance; health behavior; human immunodeficiency virus; human subject; human therapy evaluation; interview; longitudinal human study; outcomes research; patient oriented research; pharmacokinetics; phlebotomy; therapy compliance; training

DESCRIPTION (provided by applicant): This application is for a Mid-Career Investigator Award in Patient-Oriented Research (K-24). My goals in this award are to: 1) Increase research productivity in a resource poor setting and 2) Directed mentorship of promising sub-Saharan African students, medical officers, fellows and junior faculty in designing, executing, and publishing outcomes research relevant to resource-poor settings. My research to date has focused on adherence and health outcomes in impoverished HIV+ drug users in San Francisco. This has included NIMH-funded research on the biology of incomplete adherence (NIMH 54907), Directly Observed Depression Treatment to improve depression and HIV treatment outcomes in depressed homeless individuals (NIMH 63011) and a comparison of Modified Directly Observed Therapy vs. Adherence Case Management (NIMH 64388). This domestic program has identified 9 junior investigators who have collectively published 7 first author publications. More recently, I have expanded my research program to Uganda. With pilot R-21 funding from the NIAAA, we are studying adherence, pharmacokinetics and resistance to generic antiretroviral therapy (NIAAA 014784). This expanding international research program has also identified 4 talented junior investigators (2 Ugandan and 2 US investigators) with 2 manuscripts accepted for publication and an additional two in review. The K-24 mechanism is ideally suited to create sufficient protected time to expand this international research program and to provide directed mentorship of these promising investigators. My established relationship with and support of Makerere University in Uganda likely will lead to several additional promising international investigators. Furthermore, this directed goal of expanding international HIV research and mentorship is a priority for my home institution; I have the supportive commitment from my home institution to reduce my clinical and administrative responsibilities to 20% in order to achieve this goal.

描述（由申请人提供）：此申请是为以患者为导向研究的中期研究者奖（K-24）。我在该奖项中的目标是：1）提高资源差的研究生产力，以及2）有希望的撒哈拉以南非洲学生，医务人员，研究员和初级教师的指导指导，以设计，执行和发布与资源贫乏的环境相关的研究成果。迄今为止，我的研究集中在旧金山贫困的HIV+吸毒者中的依从性和健康成果上。这包括关于NIMH资助的关于不完全依从性生物学的研究（NIMH 54907），直接观察到抑郁症治疗以改善抑郁无家可归者（NIMH 63011）中的抑郁症和HIV治疗结果，并比较了经过修改的直接观察到的治疗与依从性病例管理（NIMH 64388）。该国内计划已经确定了9名二级调查人员，他们共同发表了7份第一篇作者出版物。最近，我将研究计划扩展到乌干达。借助NIAAA的R-21试点R-21，我们正在研究依从性，药代动力学和对通用抗逆转录病毒疗法的抵抗力（NIAAA 014784）。这项不断扩大的国际研究计划还确定了4位才华横溢的初级调查员（2名乌干达和2名美国调查人员），并接受了2种手稿进行出版，另外两个手稿正在审查中。 K-24机制非常适合创造足够的保护时间来扩大该国际研究计划，并为这些有前途的研究人员提供指导指导。我与乌干达的Makerere大学的建立关系和支持可能会导致其他有前途的国际调查员。 此外，扩大国际艾滋病毒研究和指导的指导目标是我的家庭机构的首要任务。为了实现这一目标，我的家庭机构的支持性承诺将我的临床和行政责任减少到20％。