Core-Behavioral Testing

核心行为测试

• 批准号: 7060632
• 负责人: JOE E SPRINGER
• 金额: $ 13.8万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7060632
• 关键词: Rodentias; behavior test; behavioral /social science research tag; biomedical facility; brain injury; spinal cord injury

SCI Testing Paradigms: Gross locomotor skill will be assessed during open field walking with the 21-point Basso, Beattie and Bresnahan (BBB) locomotor recovery scale. The horizontal ladder (Columbus Instruments) will be used to examine hindlimb locomotor function and interlimb coordination. Specific kinetic and kinematic parameters of overground locomotion will be studied and analyzed using a runway device previously described (Muir et al. 1996; Muir and Whishaw 1999). For assessment of sensory function animals will be examined using von Frey hairs for testing tactile sensation and Hargreaves' test for nociception (Stoelting Instruments). The grip strength meter (TSE Systems) is a recently developed apparatus that measures the gripping strength of the front or hind paw of either rats or mice. Blood pressure monitors (Columbus Instruments) will also be required in order to study changes in blood pressure and heart rate in a model of autonomic dysreflexia. TBI Testing Paradigms: The Morris water maze is a well accepted procedure for studying functional deficits and recovery of function following TBI and one room of the Core will be dedicated. Animals will also be tested on additional paradigms including the rotarod test (Columbus Instruments), balance beam, and the grip strength meter.

SCI测试范例：与21分贝司，Beattie和Bresnahan（BBB）运动量均衡量表一起，将评估自动运动技能的总体运动技能。水平梯子（哥伦布仪器）将用于检查后肢的运动功能和跨层配位。将使用先前描述的跑道设备研究和分析地面运动的特定动力学和运动学参数（Muir等，1996; Muir and Whishaw 1999）。为了评估感官功能的动物，将使用冯·弗雷（Von Frey）的毛发来检查触觉感觉和Hargreaves的伤害感受器（stolelting Instruments）。抓地力计（TSE系统）是一种最近开发的设备，可测量大鼠或小鼠的前爪的抓地力。为了研究自主神经性反射症模型的血压和心率的变化，还需要血压监测器（哥伦布仪器）。 TBI测试范例：莫里斯水迷宫是研究功能缺陷和核心后核心室后功能不足的一项公认的程序。动物还将在其他范式上进行测试，包括rotarod测试（哥伦布仪器），平衡梁和握力仪表。