NEUROGENETICS AND BEHAVIOR CENTER: ANIMAL TEST FACIL :RODENTS,ANIMAL MODELS

神经遗传学和行为中心：动物测试设施：啮齿动物、动物模型

• 批准号: 7153961
• 负责人: Michela Gallagher
• 金额: $ 56.51万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7153961
• 关键词: animal colony; behavioral genetics; biomedical resource; neurogenetics

DESCRIPTION (provided by applicant): The Neurogenetics and Behavior Center, supported under this award, would establish a unique resource for NIH supported research programs using gene targeting technology to study basic functions of the brain and disorders relevant to psychiatric and neurological disease. The Center, through its Administrative, Animal Testing Facility, and Data Management functions will provide behavioral assessments in three broad functional domains: sensorimotor, affective processes, and cognition, the latter to include learning, memory, and attention. Phenotypic analysis in these domains will provide an immediate service to 33 investigators/research groups listed in the application, located in Maryland at JHU and the Kennedy Krieger Institute and at other sites (Massachusetts Institute of Technology, Brown University, and the Tennessee Mouse Genome Consortium, among others). In addition to providing a facility for standard behavioral testing and data analysis, investigators in the Center, who are internationally recognized behavioral neuroscientists, will work collaboratively to develop innovative assessments appropriate to the research goals of the users. These collaborations will not only enhance the quality of current investments in research programs funded by the NIH but will make a significant contribution to the field of neurogenetics through dissemination of the Center's activities. The Center will also provide a resource for training young scientists in the wide range of expertise needed to accomplish integrative research with animal models, bridging from genomic, molecular, and cellular levels of analysis to the study of behavioral systems and functional disorders.

描述（由申请人提供）： 根据该奖项支持的神经遗传学和行为中心将使用基因靶向技术为研究大脑的基本功能和与精神病和神经系统疾病有关的疾病的基本功能建立独特的资源。该中心通过其行政，动物测试设施和数据管理功能将在三个广泛的功能领域提供行为评估：感觉运动，情感过程和认知，后者包括学习，记忆和注意力。 这些领域中的表型分析将为位于马里兰州和肯尼迪·克里格研究所（JHU）和其他地点（马萨诸塞州布朗大学，布朗大学和田纳西州小鼠基因组联盟等）的33个研究人员/研究小组提供直接服务。 除了提供标准行为测试和数据分析的设施外，该中心的研究人员是国际认可的行为神经科学家，还将共同开发适合用户研究目标的创新评估。 这些合作不仅将提高NIH资助的研究计划的当前投资质量，而且还将通过传播中心的活动为神经遗传学领域做出重大贡献。 该中心还将为培训年轻科学家提供资源，以使用动物模型来完成综合研究所需的广泛专业知识，从基因组，分子和细胞分析水平到行为系统和功能障碍的研究。