Protein Structure and Dynamics by Electron/Nuclear Paramagnetic Resonance

通过电子/核顺磁共振研究蛋白质结构和动力学

• 批准号: DP240100273
• 负责人: Prof Nicholas Cox
• 金额: $ 54.02万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240100273
• 关键词: Protein; Structure; Dynamics; Electron; Nuclear

This interdisciplinary project aims to establish new magnetic resonance methods for the analysis of protein structure and motion at low concentrations and in physiological conditions that are otherwise difficult or impossible to study. It brings together four different research groups with expertise in advanced biochemistry, modern magnetic spectroscopy and high-performance computing. The project expects to develop tools to study protein structure, protein-protein association and protein-ligand interactions of established drug-targets. Expected outcomes include new techniques that quickly inform how drugs work, providing significant benefits to many researchers studying biomolecules, and supporting Australia’s growing biotechnology sector.

这个跨学科项目旨在建立新的磁共振方法，用于在低浓度和身体状况下进行蛋白质结构和运动的分析，而在本来很难或不可能研究的物理条件下。它汇集了四个不同的研究小组，以及高级生物化学，现代磁光谱和高性能计算的专家。该项目希望开发工具来研究已建立的药物目标的蛋白质结构，蛋白质 - 蛋白质缔合和蛋白质 - 配体相互作用。预期的结果包括新技术，这些技术迅速告知药物的工作原理，为许多研究生物分子的研究人员提供了重大好处，并支持澳大利亚不断增长的生物技术领域。