The Epidemiology of Barrett's Esophagus in Children

儿童巴雷特食管的流行病学

• 批准号: 6928483
• 负责人: Mark Alan Gilger
• 金额: $ 14.85万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928483
• 关键词: Barretts esophagus; children; clinical research; data collection; disease /disorder onset; disease /disorder proneness /risk; endoscopy; epidemiology; esophagus neoplasm; histopathology; human subject; pediatrics; reflux esophagitis

DESCRIPTION (provided by applicant): Barrett's Esophagus (BE) is the only known precursor lesion for esophageal adenocarcinoma, which is the fastest rising cancer in Caucasian men in the United States. The age of onset of BE is unknown. BE results from chronic gastroesophageal reflux disease (GERD), which is known to develop during childhood. Hence, childhood GERD could be a risk factor for BE. The goal of the proposed research is to examine the epidemiology of BE in children and adolescents using retrospective as well as prospective data collected in the multicenter network project known as Pediatric Endoscopy Database System-Clinical Outcomes Research Initiative (PEDS-CORI). The Specific Aims are (1) to determine the prevalence of BE as defined by endoscopic and histologic criteria in children and adolescents undergoing upper endoscopy; and (2) to evaluate the demographic features (age, gender, ethnicity) and clinical determinants (comorbidity, GERD symptoms) of BE as defined by uniform endoscopic and histologic criteria among children and adolescents undergoing endoscopy. These aims will be achieved through two cross-sectional studies designed to obtain estimates of the prevalence of BE: a retrospective study using information collected from all PEDS-CORI sites between 1999 and 2004 (an expected 16,000 procedures), followed by a one-year prospective endoscopic study in three PEDS-CORI sites (an expected 1,800 procedures), in which additional BE-specific information will be collected. The prospective study includes rigorous standardization of the observation and recording of endoscopic and histologic findings and specific questions about potential risk factors. The long-term objectives of this research are to lay the groundwork in terms of feasibility and sample size for a prospective multicenter study involving all PEDS-CORI sites that will examine the risk factors for BE in children and adolescents.

描述（由申请人提供）： 巴雷特的食道（BE）是食管腺癌的唯一已知的前体病变，这是美国高加索男性中癌症最快的癌症。 BE的发作年龄尚不清楚。是慢性胃食管反流疾病（GERD）的结果，该疾病已知在童年时期发展。因此，童年的GERD可能是BE的危险因素。拟议的研究的目的是使用回顾性以及在多中心网络项目中收集的儿童和青少年的流行病学研究，称为儿科内窥镜数据库系统 - 临床结果研究计划（PEDS-CORI）。具体的目的是（1）确定BE的患病率由内窥镜和青少年进行上镜检查的内窥镜和组织学标准所定义； （2）评估人口特征（年龄，性别，种族）和临床决定因素（合并症，GERD症状）的BE，是由内窥镜统一的内窥镜和组织学标准所定义的。这些目标将通过两项跨截面研究旨在获得BE：回顾性研究的估计，使用从1999年至2004年之间所有PEDS-CORI站点收集的信息（预期的16,000个程序）（预期的16,000个程序），然后在三个PEDS-CORI站点（预期的1,800个过程中）进行了其他信息，该信息将是其他信息。前瞻性研究包括对内窥镜和组织学发现的观察和记录的严格标准化以及有关潜在危险因素的具体问题。这项研究的长期目标是在可行性和样本量的方面奠定基础，该研究涉及所有PEDS-CORI地点，这些研究将研究儿童和青少年的危险因素。

项目成果

Healing of Erosive Esophagitis and Improvement of Symptoms of Gastroesophageal Reflux Disease After Esomeprazole Treatment in Children 12 to 36 Months Old.

12至36个月大的儿童接受埃索美拉唑治疗后糜烂性食管炎的治愈和胃食管反流病的症状改善。

• DOI: 10.1097/mpg.0b013e3181ddcf11
• 发表时间: 2015
• 期刊: Journal of pediatric gastroenterology and nutrition
• 影响因子: 2.9
• 作者: Tolia,Vasundkara;Gilger,MarkA;Barker,PeterN;Illueca,Marta
• 通讯作者: Illueca,Marta

The prevalence of suspected Barrett's esophagus in children and adolescents: a multicenter endoscopic study.

儿童和青少年疑似巴雷特食管的患病率：一项多中心内窥镜研究。

• DOI: 10.1016/j.gie.2006.03.010
• 发表时间: 2006
• 期刊: Gastrointestinal endoscopy
• 影响因子: 7.7
• 作者: El-Serag,HashemB;Gilger,MarkA;Shub,MitchellD;Richardson,Peter;Bancroft,John
• 通讯作者: Bancroft,John

Barrett's esophagus in children and adolescents without neurodevelopmental or tracheoesophageal abnormalities: a prospective study.

无神经发育或气管食管异常的儿童和青少年的巴雷特食管：一项前瞻性研究。

• DOI: 10.1016/j.gie.2011.01.017
• 发表时间: 2011
• 期刊: Gastrointestinal endoscopy
• 影响因子: 7.7
• 作者: Nguyen,DangM;El-Serag,HashemB;Shub,Mitchell;Integlia,Mark;Henderson,Louise;Richardson,Peter;Fairly,Kenneth;Gilger,MarkA
• 通讯作者: Gilger,MarkA