Refining Measures of Lip Function

唇部功能改善措施

• 批准号: 6962555
• 负责人: CARROLL ANN TROTMAN
• 金额: $ 7.16万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6962555
• 关键词: body movement; cleft lip; clinical research; computer assisted medical decision making; congenital oral /facial /cranial defect; human data; lip; method development; model; model design /development; oral facial restoration; statistics /biometry

DESCRIPTION (provided by applicant): The goal of this R03 is to conduct secondary analyses on an existing database of facial/lip functional measures. The data was collected during an on-going, NIDCR-funded, prospective non-randomized controlled clinical trial to assess outcomes of lip revision surgery in children with a cleft lip; and consists of measures of dynamic facial movement, lip force, lip sensation, and sensory-integrative function. The individual measures provide an objective assessment of facial/lip impairment that can be used by surgeons in the decision-making process for or against lip revision in cleft patients, and in the determination of which patients would benefit from revision surgery. In this R03, statistical approaches will be applied to these measures to address the following specific aims. Specific Aim 1-Generate composite statistical measures of lip impairment from the individual functional measures. Different combinations of measures will be explored in order to produce a set of measures that more completely characterizes facial functional problems or impairment. Specific Aim 2-To adapt current, and develop new, statistical approaches to the novel application of modeling dynamic facial movement and to analyze variation in movement in terms of predictor variables, movement velocity, and compensatory movements. The hypotheses to be tested are as follows: (1) Composite measures provide a greater sensitivity of analysis of facial impairment and (a) more accurately discriminate between patients with cleft lip and non-cleft subjects, and (b) more accurately quantify the change in facial impairment in patients with cleft lip who have lip revision surgery; and (2) Adaptations of current, and the development of new, statistical techniques can characterize facial movement in terms of subject predictor variables (e.g., cleft lip versus no cleft; unilateral versus bilateral cleft lip, etc), velocity of movement, and compensatory movements appropriate for the particular subject of study. The impact of this research will be the refinement of the current impairment measures and the development of a composite measure of facial/lip impairment that encompasses the interrelationships and information among the individual measures. The developed measure(s) will provide a tremendous advantage in terms of characterizing existing and future outcomes for surgical treatment.

描述（由申请人提供）：该R03的目标是在现有的面部/唇部功能测量数据库上进行次要分析。该数据是在正在进行的，NIDCR资助的，前瞻性非随机对照临床试验中收集的，以评估唇裂儿童唇部修订手术的结果；并包括动态面部运动，唇部力，唇部感和感觉综合功能的度量。该措施提供了对面部/唇部障碍的客观评估，外科医生可以在决策过程中使用cle裂患者的唇部修订，并确定哪些患者将从修订手术中受益。在此R03中，统计方法将应用于这些措施以解决以下特定目标。特定的目标1产生唇部损伤的复合统计度量来自各个功能措施。将探索不同的措施组合，以便产生一组更彻底地表征面部功能问题或损害的措施。特定的目标2可以适应电流，并开发了新的统计方法来建模动态面部运动的新应用以及分析预测变量，运动速度和补偿运动方面的运动变化。要测试的假设如下：（1）综合措施对面部障碍分析的敏感性更大，并且（a）更准确地区分患有唇裂和非裂解受试者的患者，以及（b）更准确地量化了接受过唇cre裂的患者面部障碍的变化； （2）当前的适应以及新的统计技术的发展可以表征面部运动的特征，例如受试者预测变量（例如，唇裂与无裂缝；单侧裂口唇裂；单侧与双侧裂唇），运动速度以及运动的速度以及适合于研究特定主题的运动主题。这项研究的影响将是对当前的损害措施的完善以及面部/唇部障碍的复合度量的发展，该措施涵盖了各个措施之间的相互关系和信息。开发的措施将在表征手术治疗的现有和未来结果方面提供巨大的优势。