MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

新生儿重症监护病房的多中心网络

• 批准号: 6895903
• 负责人: CHARLES RICHARD ROSENFELD
• 金额: $ 81.78万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6895903
• 关键词: clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

This proposal is a reapplication from The University of Texas Southwestern Medical Center at Dallas to participate in the Cooperative Multicenter Neonatal Research Network (RFA: HD-00-010). Abbot R. Laptook, M.D. will serve as the Principal Investigator and the Alternate will be Walid A. Salhab, M.D. The primary teaching hospital of the UT Southwestern Medical Center is Parkland Hospital, which has the largest delivery population of any hospital in the United States. The Neonatal Intensive Care Unit (NICU) at Parkland has a bed capacity of 100 and is a state of the art facility. Adjoining Parkland Hospital is Children's Medical Center, which provides all needed specialized pediatric services for radiologic, operative, and cardiac procedures. There are a number of considerations that justify UT Southwestern continuing as one of the sites for the Network. First, a large inborn population is provided, and in spite of changes in health care delivery, Parkland Health and Hospital System has been able to maintain their delivery population, and admissions to the NICU have been relatively constant over the past decade. This reflects a well organized institutional approach to providing health care, and an established Obstetric service which is integrated within the health care delivery services of targeted communities of Dallas. Second, the UT Southwestern site offers ethnic diversity for the Network by providing a large number of Hispanic patients. Currently, the delivery population is 77% Hispanic and admissions to the NICU are 64% Hispanic. Third, the UT Southwestern site has a proven track record within the Network. It has been a member institution since the inception of the Network and continues to have a well organized system with a high percent of eligible infants enrolled in randomized trials, limited errors in conducting studies, complete data acquisition, and an almost 90% follow-up rate. Fourth, the PI provides expertise in cerebral metabolism and blood flow which will benefit the design and implementation of studies directed at perinatal brain damage. Finally, the Division of Neonatal-Perinatal Medicine at UT Southwestern has a strong commitment to clinical research and maintains a clinical management approach, which is reluctant to adopt new therapies without sufficient evaluation and evidence.

该建议是达拉斯西南医学中心的重新申请，以参加合作多中心新生儿研究网络（RFA：HD-00-010）。医学博士Abbot R. Laptook将担任首席研究员，替代人将是M.D. Walid A. Salhab，UT西南医疗中心的初级教学医院是Parkland医院，该医院是美国任何医院的最多分娩人口。帕克兰（Parkland）的新生儿重症监护室（NICU）的床容量为100，是最先进的设施。毗邻Parkland医院是儿童医疗中心，该中心为放射线，手术和心脏手术提供所有必需的专业儿科服务。有许多考虑因素证明西南继续是该网络的网站之一。首先，提供了大量的天生人口，尽管医疗保健提供了变化，但帕克兰健康和医院系统仍然能够维持其分娩人群，并且在过去十年中，对NICU的招生相对持续不变。这反映了一种组织良好的机构方法来提供医疗保健，以及一项已建立的产科服务，该服务纳入了达拉斯有针对性社区的医疗保健服务中。其次，UT西南网站通过提供大量西班牙裔患者为网络提供种族多样性。目前，分娩人口为77％的西班牙裔，对NICU的录取为64％的西班牙裔。第三，UT西南站点在网络中具有良好的往绩记录。自从网络成立以来，它一直是会员机构，并且继续拥有一个组织良好的系统，其中有符合条件的婴儿在随机试验，进行研究的有限错误，完整的数据获取和接近90％的随访率中。第四，PI提供了脑代谢和血流方面的专业知识，这将有助于针对围产期脑损伤的研究的设计和实施。最后，UT Southwestern的新生儿 - 耕地医学部门对临床研究具有坚定的承诺，并保持了一种临床管理方法，该方法不愿采用新的疗法而没有足够的评估和证据。